Alfalfa Gene Editing Database
| Query id | Subject id | identity % | alignment length | mis matches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MsG0180003616.01.T01 | XP_018459315.1 | 45.631 | 309 | 146 | 6 | 2 | 310 | 33 | 319 | 3.41E-86 | 272 |
| Query id | Subject id | identity % | alignment length | mis matches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
|---|
| Query id | Subject id | identity % | alignment length | mis matches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MsG0180003616.01.T01 | A0A6J0LGH1 | 45.631 | 309 | 146 | 6 | 2 | 310 | 33 | 319 | 1.63e-86 | 272 |
| Gene ID | Type | Classification |
|---|
| Gene ID | Type | Classification |
|---|
Co-expression Network
| Gene1 | Gene2 | correlation coefficient | p_value | FDR |
|---|---|---|---|---|
| MsG0180000163.01 | MsG0180003616.01 | 0.840293 | 9.490255e-58 | 1.345687e-54 |
| MsG0180003616.01 | MsG0880045123.01 | 0.827578 | 1.448217e-54 | 1.403671e-51 |
PPI
| Gene1 | Gene2 | Type |
|---|
| Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MsG0180003616.01.T01 | MTR_4g037355 | 41.176 | 136 | 60 | 3 | 125 | 260 | 1 | 116 | 1.49e-22 | 91.7 |
| MsG0180003616.01.T01 | MTR_7g062720 | 38.393 | 112 | 63 | 1 | 5 | 116 | 37 | 142 | 2.33e-22 | 92.0 |
| MsG0180003616.01.T01 | MTR_5g061150 | 35.354 | 99 | 64 | 0 | 22 | 120 | 38 | 136 | 2.62e-18 | 80.5 |
| MsG0180003616.01.T01 | MTR_4g112730 | 57.971 | 69 | 28 | 1 | 113 | 181 | 2 | 69 | 2.68e-18 | 79.0 |
| Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
|---|
Find 64 sgRNAs with CRISPR-Local
Find 84 sgRNAs with CRISPR-GE
CRISPR-Local
| sgRNA_sequence | on_target_score | Position | Region |
|---|---|---|---|
| TGGATCAATGGAACAAATTA+AGG | 0.196151 | 1:-65264720 | MsG0180003616.01.T01:CDS |
| AGTCTTATTGCCCTCATTAA+TGG | 0.201947 | 1:-65264740 | MsG0180003616.01.T01:CDS |
| AAAGCTGTGGCGTTTATTTC+AGG | 0.210383 | 1:+65264424 | None:intergenic |
| GACAAAATTAAGGCAAGATT+TGG | 0.257188 | 1:-65264775 | MsG0180003616.01.T01:CDS |
| GATTCTTGAGGGAGACGATT+TGG | 0.271296 | 1:-65264917 | MsG0180003616.01.T01:CDS |
| CACGGCCTCCACCACGAAAA+TGG | 0.277262 | 1:+65264308 | None:intergenic |
| CATAGGAGAAGATATTAATA+TGG | 0.311554 | 1:-65264014 | MsG0180003616.01.T01:CDS |
| ATTTACTGAATACTCTGATT+TGG | 0.313227 | 1:-65264530 | MsG0180003616.01.T01:CDS |
| CTTGATGATTCTTGTTGGTT+TGG | 0.339105 | 1:+65264248 | None:intergenic |
| GAAGAGGTTATATGAATTAT+AGG | 0.339571 | 1:-65264285 | MsG0180003616.01.T01:CDS |
| GGGAGATGTCCCAGAGGAAT+TGG | 0.345733 | 1:-65264896 | MsG0180003616.01.T01:CDS |
| ATTCTTGAGGGAGACGATTT+GGG | 0.354692 | 1:-65264916 | MsG0180003616.01.T01:CDS |
| AAGACAGGTAGTATCATTCT+TGG | 0.359896 | 1:+65264051 | None:intergenic |
| AATTGAGTATCTTGCATGTT+GGG | 0.360791 | 1:-65264949 | None:intergenic |
| TTTACCTTGATGATTCTTGT+TGG | 0.362649 | 1:+65264243 | None:intergenic |
| CTTGAGGCTGCTGATTTCAT+AGG | 0.363536 | 1:-65264031 | MsG0180003616.01.T01:CDS |
| GATTTCTAGAGGGACCTTCC+TGG | 0.373636 | 1:+65264209 | None:intergenic |
| CATAGCCACCACGTCCTCTT+TGG | 0.374275 | 1:+65264374 | None:intergenic |
| CGTGGTGGCTATGCTCGTTT+TGG | 0.395091 | 1:-65264364 | MsG0180003616.01.T01:CDS |
| ACAAAATTAAGGCAAGATTT+GGG | 0.416566 | 1:-65264774 | MsG0180003616.01.T01:CDS |
| TATAACTGAAAAGGAAAAGT+TGG | 0.422757 | 1:-65264617 | MsG0180003616.01.T01:CDS |
| CGTGGTGGAGGCCGTGGAAG+AGG | 0.431707 | 1:-65264301 | MsG0180003616.01.T01:CDS |
| TGCCCTCATTAATGGATCAA+TGG | 0.432677 | 1:-65264732 | MsG0180003616.01.T01:CDS |
| TTGTTCCTGTAGGACGTAAC+TGG | 0.439062 | 1:+65264455 | None:intergenic |
| AGATACAAAGAATCTGTTGA+TGG | 0.446469 | 1:-65264109 | MsG0180003616.01.T01:CDS |
| TGGCAAAACTATAACTGAAA+AGG | 0.467052 | 1:-65264626 | MsG0180003616.01.T01:CDS |
| TTGGTTTGGTCATATTTGAA+AGG | 0.470217 | 1:+65264262 | None:intergenic |
| ATCTGTTGATGGAAAGGAAA+AGG | 0.477668 | 1:-65264098 | MsG0180003616.01.T01:CDS |
| AGACAGGTAGTATCATTCTT+GGG | 0.483328 | 1:+65264052 | None:intergenic |
| ATCAAGCACCACATTGATGA+TGG | 0.492315 | 1:-65264844 | MsG0180003616.01.T01:CDS |
| TGCAACAACAATATAGAATG+AGG | 0.496917 | 1:-65264555 | MsG0180003616.01.T01:CDS |
| AACAAGAATCATCAAGGTAA+AGG | 0.504207 | 1:-65264241 | MsG0180003616.01.T01:CDS |
| AACCACCAGTTACGTCCTAC+AGG | 0.509195 | 1:-65264460 | MsG0180003616.01.T01:CDS |
| GGACTCGACAAGATTCTTGA+GGG | 0.509272 | 1:-65264928 | MsG0180003616.01.T01:CDS |
| GTTCCATTGATCCATTAATG+AGG | 0.509644 | 1:+65264729 | None:intergenic |
| CAAAGAATCTGTTGATGGAA+AGG | 0.510693 | 1:-65264104 | MsG0180003616.01.T01:CDS |
| TGTTATAGATGCGGAAAGAA+AGG | 0.513070 | 1:-65264175 | MsG0180003616.01.T01:CDS |
| TTCCATTGATCCATTAATGA+GGG | 0.533283 | 1:+65264730 | None:intergenic |
| GATGCGGAAAGAAAGGTCAT+TGG | 0.533423 | 1:-65264168 | MsG0180003616.01.T01:CDS |
| CGTGGTCGAGGCAGAAGTCA+TGG | 0.554869 | 1:-65264337 | MsG0180003616.01.T01:CDS |
| GAAATCAGCAGCCTCAAGAC+AGG | 0.558951 | 1:+65264036 | None:intergenic |
| CAAACCAACAAGAATCATCA+AGG | 0.574004 | 1:-65264247 | MsG0180003616.01.T01:CDS |
| TTTGGTTACAGCTCTTCTAG+TGG | 0.574259 | 1:-65264512 | MsG0180003616.01.T01:CDS |
| AGGTAAAGGTAAAAGCATCC+AGG | 0.575090 | 1:-65264227 | MsG0180003616.01.T01:CDS |
| GGATATGCCATTGTTCCTGT+AGG | 0.578642 | 1:+65264445 | None:intergenic |
| GCAACAACAATATAGAATGA+GGG | 0.579939 | 1:-65264554 | MsG0180003616.01.T01:CDS |
| GGGACTCGACAAGATTCTTG+AGG | 0.580948 | 1:-65264929 | MsG0180003616.01.T01:CDS |
| AATTCATATAACCTCTTCCA+CGG | 0.595635 | 1:+65264290 | None:intergenic |
| TTCCTGTAGGACGTAACTGG+TGG | 0.602450 | 1:+65264458 | None:intergenic |
| GCAATATCACTTGAGATGCA+TGG | 0.608661 | 1:+65264575 | None:intergenic |
| TATAATCGCCAAAGAGGACG+TGG | 0.608957 | 1:-65264382 | MsG0180003616.01.T01:CDS |
| TGTTGATGGAAAGGAAAAGG+AGG | 0.612844 | 1:-65264095 | MsG0180003616.01.T01:CDS |
| ACGATCATCATGATTTCTAG+AGG | 0.627654 | 1:+65264198 | None:intergenic |
| GTCATTGGTCTAAAGCATGT+AGG | 0.629444 | 1:-65264153 | MsG0180003616.01.T01:CDS |
| GATGATCGTTGTTATAGATG+CGG | 0.637106 | 1:-65264184 | MsG0180003616.01.T01:CDS |
| GAATGATACTACCTGTCTTG+AGG | 0.637144 | 1:-65264047 | MsG0180003616.01.T01:CDS |
| CGATCATCATGATTTCTAGA+GGG | 0.638172 | 1:+65264199 | None:intergenic |
| GGTGGTTATAATCGCCAAAG+AGG | 0.642086 | 1:-65264388 | MsG0180003616.01.T01:CDS |
| GTTACGTCCTACAGGAACAA+TGG | 0.651542 | 1:-65264452 | MsG0180003616.01.T01:CDS |
| AAAGGTAAAAGCATCCAGGA+AGG | 0.661440 | 1:-65264223 | MsG0180003616.01.T01:CDS |
| ACGCCCTTGATTAAAAGCTG+TGG | 0.664043 | 1:+65264411 | None:intergenic |
| AATCGCCAAAGAGGACGTGG+TGG | 0.698905 | 1:-65264379 | MsG0180003616.01.T01:CDS |
| TTTGTAATCCATCATCAATG+TGG | 0.715751 | 1:+65264836 | None:intergenic |
| CGATTTGGGAGATGTCCCAG+AGG | 0.725435 | 1:-65264902 | MsG0180003616.01.T01:CDS |
CRISPR-GE
| badsite warning | sgRNA_sequence | Strand | Position | Region | GC_content |
|---|---|---|---|---|---|
| ! | ACAAAATTAAGGCAAGATTT+GGG | - | Chr1:65264169-65264188 | MsG0180003616.01.T01:CDS | 25.0% |
| ! | ATTTACTGAATACTCTGATT+TGG | - | Chr1:65264413-65264432 | MsG0180003616.01.T01:CDS | 25.0% |
| ! | CATAGGAGAAGATATTAATA+TGG | - | Chr1:65264929-65264948 | MsG0180003616.01.T01:CDS | 25.0% |
| ! | GAAGAGGTTATATGAATTAT+AGG | - | Chr1:65264658-65264677 | MsG0180003616.01.T01:CDS | 25.0% |
| ! | TATAACTGAAAAGGAAAAGT+TGG | - | Chr1:65264326-65264345 | MsG0180003616.01.T01:CDS | 25.0% |
| !! | AAAAGATCCCAAGATTTTAT+GGG | - | Chr1:65264146-65264165 | MsG0180003616.01.T01:CDS | 25.0% |
| !! | AATTTTGTCCCATAAAATCT+TGG | + | Chr1:65264157-65264176 | None:intergenic | 25.0% |
| !! | ATTGCACAATTAGAATTTTG+TGG | - | Chr1:65264297-65264316 | MsG0180003616.01.T01:CDS | 25.0% |
| !! | ATTTTGTCCCATAAAATCTT+GGG | + | Chr1:65264156-65264175 | None:intergenic | 25.0% |
| !! | GATTTTATGGGACAAAATTA+AGG | - | Chr1:65264158-65264177 | MsG0180003616.01.T01:CDS | 25.0% |
| !!! | CAACAACAGTTTTATAATCT+TGG | + | Chr1:65264251-65264270 | None:intergenic | 25.0% |
| AACAAGAATCATCAAGGTAA+AGG | - | Chr1:65264702-65264721 | MsG0180003616.01.T01:CDS | 30.0% | |
| AATTCATATAACCTCTTCCA+CGG | + | Chr1:65264656-65264675 | None:intergenic | 30.0% | |
| AGATACAAAGAATCTGTTGA+TGG | - | Chr1:65264834-65264853 | MsG0180003616.01.T01:CDS | 30.0% | |
| GACAAAATTAAGGCAAGATT+TGG | - | Chr1:65264168-65264187 | MsG0180003616.01.T01:CDS | 30.0% | |
| GCAACAACAATATAGAATGA+GGG | - | Chr1:65264389-65264408 | MsG0180003616.01.T01:CDS | 30.0% | |
| TGCAACAACAATATAGAATG+AGG | - | Chr1:65264388-65264407 | MsG0180003616.01.T01:CDS | 30.0% | |
| TGGATCAATGGAACAAATTA+AGG | - | Chr1:65264223-65264242 | MsG0180003616.01.T01:CDS | 30.0% | |
| TGGCAAAACTATAACTGAAA+AGG | - | Chr1:65264317-65264336 | MsG0180003616.01.T01:CDS | 30.0% | |
| TTCCATTGATCCATTAATGA+GGG | + | Chr1:65264216-65264235 | None:intergenic | 30.0% | |
| TTTGTAATCCATCATCAATG+TGG | + | Chr1:65264110-65264129 | None:intergenic | 30.0% | |
| ! | CAAAAGATCCCAAGATTTTA+TGG | - | Chr1:65264145-65264164 | MsG0180003616.01.T01:CDS | 30.0% |
| ! | TATCTTTTACAGAGATACTC+TGG | + | Chr1:65264819-65264838 | None:intergenic | 30.0% |
| ! | TTTACCTTGATGATTCTTGT+TGG | + | Chr1:65264703-65264722 | None:intergenic | 30.0% |
| !! | TTGGTTTGGTCATATTTGAA+AGG | + | Chr1:65264684-65264703 | None:intergenic | 30.0% |
| AAGACAGGTAGTATCATTCT+TGG | + | Chr1:65264895-65264914 | None:intergenic | 35.0% | |
| AGACAGGTAGTATCATTCTT+GGG | + | Chr1:65264894-65264913 | None:intergenic | 35.0% | |
| CAAACCAACAAGAATCATCA+AGG | - | Chr1:65264696-65264715 | MsG0180003616.01.T01:CDS | 35.0% | |
| GATGATCGTTGTTATAGATG+CGG | - | Chr1:65264759-65264778 | MsG0180003616.01.T01:CDS | 35.0% | |
| GTTCCATTGATCCATTAATG+AGG | + | Chr1:65264217-65264236 | None:intergenic | 35.0% | |
| TGTTATAGATGCGGAAAGAA+AGG | - | Chr1:65264768-65264787 | MsG0180003616.01.T01:CDS | 35.0% | |
| ! | ACGATCATCATGATTTCTAG+AGG | + | Chr1:65264748-65264767 | None:intergenic | 35.0% |
| ! | ATCTGTTGATGGAAAGGAAA+AGG | - | Chr1:65264845-65264864 | MsG0180003616.01.T01:CDS | 35.0% |
| ! | CAAAGAATCTGTTGATGGAA+AGG | - | Chr1:65264839-65264858 | MsG0180003616.01.T01:CDS | 35.0% |
| ! | CGATCATCATGATTTCTAGA+GGG | + | Chr1:65264747-65264766 | None:intergenic | 35.0% |
| ! | CTTGATGATTCTTGTTGGTT+TGG | + | Chr1:65264698-65264717 | None:intergenic | 35.0% |
| ! | TTTTCTTTGCCAATTCCTCT+GGG | + | Chr1:65264059-65264078 | None:intergenic | 35.0% |
| ! | TTTTTCTTTGCCAATTCCTC+TGG | + | Chr1:65264060-65264079 | None:intergenic | 35.0% |
| !! | AGTCTTATTGCCCTCATTAA+TGG | - | Chr1:65264203-65264222 | MsG0180003616.01.T01:CDS | 35.0% |
| AAAGCTGTGGCGTTTATTTC+AGG | + | Chr1:65264522-65264541 | None:intergenic | 40.0% | |
| ATCAAGCACCACATTGATGA+TGG | - | Chr1:65264099-65264118 | MsG0180003616.01.T01:CDS | 40.0% | |
| ATTCTTGAGGGAGACGATTT+GGG | - | Chr1:65264027-65264046 | MsG0180003616.01.T01:CDS | 40.0% | |
| GAATGATACTACCTGTCTTG+AGG | - | Chr1:65264896-65264915 | MsG0180003616.01.T01:CDS | 40.0% | |
| GCAATATCACTTGAGATGCA+TGG | + | Chr1:65264371-65264390 | None:intergenic | 40.0% | |
| TTTGGTTACAGCTCTTCTAG+TGG | - | Chr1:65264431-65264450 | MsG0180003616.01.T01:CDS | 40.0% | |
| ! | AACGCCACAGCTTTTAATCA+AGG | - | Chr1:65264528-65264547 | MsG0180003616.01.T01:CDS | 40.0% |
| ! | ACGCCACAGCTTTTAATCAA+GGG | - | Chr1:65264529-65264548 | MsG0180003616.01.T01:CDS | 40.0% |
| ! | GTCATTGGTCTAAAGCATGT+AGG | - | Chr1:65264790-65264809 | MsG0180003616.01.T01:CDS | 40.0% |
| ! | TGCCCTCATTAATGGATCAA+TGG | - | Chr1:65264211-65264230 | MsG0180003616.01.T01:CDS | 40.0% |
| ! | TGTTGATGGAAAGGAAAAGG+AGG | - | Chr1:65264848-65264867 | MsG0180003616.01.T01:CDS | 40.0% |
| !! | AAAGGTAAAAGCATCCAGGA+AGG | - | Chr1:65264720-65264739 | MsG0180003616.01.T01:CDS | 40.0% |
| !! | AGGTAAAGGTAAAAGCATCC+AGG | - | Chr1:65264716-65264735 | MsG0180003616.01.T01:CDS | 40.0% |
| ACGCCCTTGATTAAAAGCTG+TGG | + | Chr1:65264535-65264554 | None:intergenic | 45.0% | |
| GATGCGGAAAGAAAGGTCAT+TGG | - | Chr1:65264775-65264794 | MsG0180003616.01.T01:CDS | 45.0% | |
| GATTCTTGAGGGAGACGATT+TGG | - | Chr1:65264026-65264045 | MsG0180003616.01.T01:CDS | 45.0% | |
| GGACTCGACAAGATTCTTGA+GGG | - | Chr1:65264015-65264034 | MsG0180003616.01.T01:CDS | 45.0% | |
| GGATATGCCATTGTTCCTGT+AGG | + | Chr1:65264501-65264520 | None:intergenic | 45.0% | |
| GGTGGTTATAATCGCCAAAG+AGG | - | Chr1:65264555-65264574 | MsG0180003616.01.T01:CDS | 45.0% | |
| GTTACGTCCTACAGGAACAA+TGG | - | Chr1:65264491-65264510 | MsG0180003616.01.T01:CDS | 45.0% | |
| TATAATCGCCAAAGAGGACG+TGG | - | Chr1:65264561-65264580 | MsG0180003616.01.T01:CDS | 45.0% | |
| TTGTTCCTGTAGGACGTAAC+TGG | + | Chr1:65264491-65264510 | None:intergenic | 45.0% | |
| ! | ACAGCTTTTAATCAAGGGCG+TGG | - | Chr1:65264534-65264553 | MsG0180003616.01.T01:CDS | 45.0% |
| ! | CATGGTCGAAACCATTTTCG+TGG | - | Chr1:65264624-65264643 | MsG0180003616.01.T01:CDS | 45.0% |
| !! | CTTGAGGCTGCTGATTTCAT+AGG | - | Chr1:65264912-65264931 | MsG0180003616.01.T01:CDS | 45.0% |
| AACCACCAGTTACGTCCTAC+AGG | - | Chr1:65264483-65264502 | MsG0180003616.01.T01:CDS | 50.0% | |
| GAAATCAGCAGCCTCAAGAC+AGG | + | Chr1:65264910-65264929 | None:intergenic | 50.0% | |
| GGGACTCGACAAGATTCTTG+AGG | - | Chr1:65264014-65264033 | MsG0180003616.01.T01:CDS | 50.0% | |
| TTCCTGTAGGACGTAACTGG+TGG | + | Chr1:65264488-65264507 | None:intergenic | 50.0% | |
| ! | CGAAACCATTTTCGTGGTGG+AGG | - | Chr1:65264630-65264649 | MsG0180003616.01.T01:CDS | 50.0% |
| ! | GATTTCTAGAGGGACCTTCC+TGG | + | Chr1:65264737-65264756 | None:intergenic | 50.0% |
| ! | GGTCGAAACCATTTTCGTGG+TGG | - | Chr1:65264627-65264646 | MsG0180003616.01.T01:CDS | 50.0% |
| !! | GCTTTTAATCAAGGGCGTGG+TGG | - | Chr1:65264537-65264556 | MsG0180003616.01.T01:CDS | 50.0% |
| !! | TATGCTCGTTTTGGTGGTCG+TGG | - | Chr1:65264588-65264607 | MsG0180003616.01.T01:CDS | 50.0% |
| AATCGCCAAAGAGGACGTGG+TGG | - | Chr1:65264564-65264583 | MsG0180003616.01.T01:CDS | 55.0% | |
| CATAGCCACCACGTCCTCTT+TGG | + | Chr1:65264572-65264591 | None:intergenic | 55.0% | |
| GGGAGATGTCCCAGAGGAAT+TGG | - | Chr1:65264047-65264066 | MsG0180003616.01.T01:CDS | 55.0% | |
| ! | CGATTTGGGAGATGTCCCAG+AGG | - | Chr1:65264041-65264060 | MsG0180003616.01.T01:CDS | 55.0% |
| ! | CGTGGTGGCTATGCTCGTTT+TGG | - | Chr1:65264579-65264598 | MsG0180003616.01.T01:CDS | 55.0% |
| ! | GGTGGCTATGCTCGTTTTGG+TGG | - | Chr1:65264582-65264601 | MsG0180003616.01.T01:CDS | 55.0% |
| CACGGCCTCCACCACGAAAA+TGG | + | Chr1:65264638-65264657 | None:intergenic | 60.0% | |
| CGTGGTCGAGGCAGAAGTCA+TGG | - | Chr1:65264606-65264625 | MsG0180003616.01.T01:CDS | 60.0% | |
| !! | CATTTTCGTGGTGGAGGCCG+TGG | - | Chr1:65264636-65264655 | MsG0180003616.01.T01:CDS | 60.0% |
| !! | CGTTTTGGTGGTCGTGGTCG+AGG | - | Chr1:65264594-65264613 | MsG0180003616.01.T01:CDS | 60.0% |
| ! | CGTGGTGGAGGCCGTGGAAG+AGG | - | Chr1:65264642-65264661 | MsG0180003616.01.T01:CDS | 70.0% |
| Chromosome | Type | Strat | End | Strand | Name |
|---|---|---|---|---|---|
| Chr1 | gene | 65264009 | 65264956 | 65264009 | ID=MsG0180003616.01;Name=MsG0180003616.01 |
| Chr1 | mRNA | 65264009 | 65264956 | 65264009 | ID=MsG0180003616.01.T01;Parent=MsG0180003616.01;Name=MsG0180003616.01.T01;_AED=0.62;_eAED=0.62;_QI=0|-1|0|1|-1|1|1|0|315 |
| Chr1 | exon | 65264009 | 65264956 | 65264009 | ID=MsG0180003616.01.T01:exon:50576;Parent=MsG0180003616.01.T01 |
| Chr1 | CDS | 65264009 | 65264956 | 65264009 | ID=MsG0180003616.01.T01:cds;Parent=MsG0180003616.01.T01 |
| Gene Sequence |
| Protein sequence |