Alfalfa Gene Editing Database
| Query id | Subject id | identity % | alignment length | mis matches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Msa1467010 | KEH38601.1 | 99.213 | 127 | 1 | 0 | 1 | 127 | 38 | 164 | 1.42e-86 | 259 |
| Query id | Subject id | identity % | alignment length | mis matches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Msa1467010 | sp|P16273|PRPX_HORVU | 49.565 | 115 | 56 | 1 | 1 | 113 | 103 | 217 | 1.44e-32 | 117 |
| Query id | Subject id | identity % | alignment length | mis matches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Msa1467010 | A0A072VAF8 | 99.213 | 127 | 1 | 0 | 1 | 127 | 38 | 164 | 6.77e-87 | 259 |
| Gene ID | Type | Classification |
|---|
| Gene ID | Type | Classification |
|---|
Co-expression Network
| Gene1 | Gene2 | correlation coefficient | p_value | FDR |
|---|---|---|---|---|
| Msa1348950 | Msa1467010 | 0.821766 | 3.391042e-53 | -8.615850e-47 |
| Msa0323610 | Msa1467010 | 0.802553 | 5.312323e-49 | -8.615850e-47 |
PPI
| Gene1 | Gene2 | Type |
|---|
| Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Msa1467010 | MtrunA17_Chr2g0315561 | 99.213 | 127 | 1 | 0 | 1 | 127 | 101 | 227 | 7.85e-90 | 259 |
| Msa1467010 | MtrunA17_Chr2g0315601 | 89.764 | 127 | 13 | 0 | 1 | 127 | 101 | 227 | 7.69e-83 | 242 |
| Msa1467010 | MtrunA17_Chr8g0359751 | 73.282 | 131 | 30 | 2 | 1 | 126 | 106 | 236 | 5.44e-67 | 202 |
| Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Msa1467010 | AT1G78780.1 | 64.748 | 139 | 37 | 2 | 1 | 127 | 38 | 176 | 3.28e-62 | 188 |
| Msa1467010 | AT1G78780.4 | 64.748 | 139 | 37 | 2 | 1 | 127 | 97 | 235 | 1.21e-61 | 189 |
| Msa1467010 | AT1G78780.2 | 64.748 | 139 | 37 | 2 | 1 | 127 | 100 | 238 | 1.34e-61 | 189 |
| Msa1467010 | AT1G78780.3 | 64.748 | 139 | 37 | 2 | 1 | 127 | 114 | 252 | 2.21e-61 | 189 |
| Msa1467010 | AT1G78780.5 | 64.748 | 139 | 37 | 2 | 1 | 127 | 114 | 252 | 2.21e-61 | 189 |
Find 21 sgRNAs with CRISPR-Local
Find 124 sgRNAs with CRISPR-GE
CRISPR-Local
| sgRNA_sequence | on_target_score | Position | Region |
|---|---|---|---|
| CTGAAATTGCTTTCAAGTTT+AGG | 0.246221 | tig0049574:-836 | Msa1467010:CDS |
| CTAAACTTGAAAGCAATTTC+AGG | 0.282078 | tig0049574:+820 | Msa1467010:intergenic |
| TGCTTTCAAGTTTAGGCATT+GGG | 0.293525 | tig0049574:-829 | Msa1467010:CDS |
| GGGAAGATGGTCCAATTCTT+TGG | 0.327141 | tig0049574:-768 | Msa1467010:CDS |
| GATGGTCCAATTCTTTGGTC+TGG | 0.350753 | tig0049574:-763 | Msa1467010:CDS |
| TTCAAGGGACATTCCCCTAC+TGG | 0.422890 | tig0049574:-789 | Msa1467010:CDS |
| GAGTTCCCAGACCAAAGAAT+TGG | 0.426282 | tig0049574:+740 | Msa1467010:intergenic |
| ACTTCCCATGCAAACCCTCT+TGG | 0.426714 | tig0049574:+865 | Msa1467010:intergenic |
| ATGGTCCAATTCTTTGGTCT+GGG | 0.454410 | tig0049574:-762 | Msa1467010:CDS |
| GTCTCTTCATTTGACTTGTA+CGG | 0.456033 | tig0049574:+925 | Msa1467010:intergenic |
| GAAGTGATTAAAGTTTATAC+AGG | 0.461844 | tig0049574:-864 | Msa1467010:CDS |
| TTGCTTTCAAGTTTAGGCAT+TGG | 0.497447 | tig0049574:-830 | Msa1467010:CDS |
| ACATTCCCCTACTGGGAAGA+TGG | 0.513266 | tig0049574:-781 | Msa1467010:CDS |
| CTTTGGTCTGGGAACTCTCA+AGG | 0.519446 | tig0049574:-751 | Msa1467010:CDS |
| TCAAGGGACATTCCCCTACT+GGG | 0.534157 | tig0049574:-788 | Msa1467010:CDS |
| ATTGGACCATCTTCCCAGTA+GGG | 0.563870 | tig0049574:+758 | Msa1467010:intergenic |
| AATTGGACCATCTTCCCAGT+AGG | 0.580984 | tig0049574:+757 | Msa1467010:intergenic |
| GTAGGGGAATGTCCCTTGAA+AGG | 0.591507 | tig0049574:+775 | Msa1467010:intergenic |
| GCTTTCAAGTTTAGGCATTG+GGG | 0.594203 | tig0049574:-828 | Msa1467010:CDS |
| AACTTGAAAGCAATTTCAGG+TGG | 0.634134 | tig0049574:+823 | Msa1467000:intergenic |
| TTGGACCATCTTCCCAGTAG+GGG | 0.659212 | tig0049574:+759 | Msa1467000:intergenic |
CRISPR-GE
| badsite warning | sgRNA_sequence | Strand | Position | Region | GC_content |
|---|---|---|---|---|---|
| !! | AAAATTATCACTAATTAAAA+TGG | - | tig0049574:467-486 | Msa1467010:intron | 10.0% |
| !! | TATATAAAATCTATTATTGA+GGG | + | tig0049574:680-699 | Msa1467010:intergenic | 10.0% |
| !! | ATATATAAAATCTATTATTG+AGG | + | tig0049574:681-700 | Msa1467010:intergenic | 10.0% |
| !! | AAAATTATCACTAATTAAAA+TGG | - | tig0049574:467-486 | Msa1467010:intron | 10.0% |
| !! | TATATAAAATCTATTATTGA+GGG | + | tig0049574:680-699 | Msa1467010:intergenic | 10.0% |
| !! | ATATATAAAATCTATTATTG+AGG | + | tig0049574:681-700 | Msa1467010:intergenic | 10.0% |
| !!! | ATGAAAAATTTGTTTTTATC+AGG | + | tig0049574:347-366 | Msa1467010:intergenic | 15.0% |
| !!! | ATTTTACACTTTTTTTTTGA+AGG | - | tig0049574:501-520 | Msa1467010:intron | 15.0% |
| !! | AAATAAAAACTCATAAAGTA+GGG | + | tig0049574:757-776 | Msa1467010:intergenic | 15.0% |
| !!! | TGATCAATATTTTTTAACAT+AGG | - | tig0049574:857-876 | Msa1467010:CDS | 15.0% |
| !!! | ATGAAAAATTTGTTTTTATC+AGG | + | tig0049574:347-366 | Msa1467010:intergenic | 15.0% |
| !!! | ATTTTACACTTTTTTTTTGA+AGG | - | tig0049574:501-520 | Msa1467010:intron | 15.0% |
| !! | AAATAAAAACTCATAAAGTA+GGG | + | tig0049574:757-776 | Msa1467010:intergenic | 15.0% |
| !!! | TGATCAATATTTTTTAACAT+AGG | - | tig0049574:857-876 | Msa1467010:CDS | 15.0% |
| !! | TGCTCTTAAAAAAATGTATA+TGG | + | tig0049574:389-408 | Msa1467010:intergenic | 20.0% |
| !!! | ATGTCTAATGATATTTTTAG+AGG | - | tig0049574:614-633 | Msa1467010:intron | 20.0% |
| !! | GAAATAAAAACTCATAAAGT+AGG | + | tig0049574:758-777 | Msa1467010:intergenic | 20.0% |
| !!! | TCAATATTTTTTAACATAGG+TGG | - | tig0049574:860-879 | Msa1467010:CDS | 20.0% |
| !! | TGCTCTTAAAAAAATGTATA+TGG | + | tig0049574:389-408 | Msa1467010:intergenic | 20.0% |
| !!! | ATGTCTAATGATATTTTTAG+AGG | - | tig0049574:614-633 | Msa1467010:intron | 20.0% |
| !! | GAAATAAAAACTCATAAAGT+AGG | + | tig0049574:758-777 | Msa1467010:intergenic | 20.0% |
| !!! | TCAATATTTTTTAACATAGG+TGG | - | tig0049574:860-879 | Msa1467010:CDS | 20.0% |
| ! | GAAGTGATTAAAGTTTATAC+AGG | - | tig0049574:131-150 | Msa1467010:intron | 25.0% |
| !! | ATCAGGAATTCTTAAACTTT+TGG | + | tig0049574:330-349 | Msa1467010:intergenic | 25.0% |
| !!! | TCTAATGATATTTTTAGAGG+AGG | - | tig0049574:617-636 | Msa1467010:intron | 25.0% |
| !! | TTTTATCACCCTTTACATTT+TGG | - | tig0049574:799-818 | Msa1467010:CDS | 25.0% |
| !! | TTTATCACCCTTTACATTTT+GGG | - | tig0049574:800-819 | Msa1467010:CDS | 25.0% |
| ! | ATCAAATCCCAAAATGTAAA+GGG | + | tig0049574:810-829 | Msa1467010:intergenic | 25.0% |
| ! | TATCAAATCCCAAAATGTAA+AGG | + | tig0049574:811-830 | Msa1467010:intergenic | 25.0% |
| ! | GAAGTGATTAAAGTTTATAC+AGG | - | tig0049574:131-150 | Msa1467010:intron | 25.0% |
| !! | ATCAGGAATTCTTAAACTTT+TGG | + | tig0049574:330-349 | Msa1467010:intergenic | 25.0% |
| !!! | TCTAATGATATTTTTAGAGG+AGG | - | tig0049574:617-636 | Msa1467010:intron | 25.0% |
| !! | TTTTATCACCCTTTACATTT+TGG | - | tig0049574:799-818 | Msa1467010:CDS | 25.0% |
| !! | TTTATCACCCTTTACATTTT+GGG | - | tig0049574:800-819 | Msa1467010:CDS | 25.0% |
| ! | ATCAAATCCCAAAATGTAAA+GGG | + | tig0049574:810-829 | Msa1467010:intergenic | 25.0% |
| ! | TATCAAATCCCAAAATGTAA+AGG | + | tig0049574:811-830 | Msa1467010:intergenic | 25.0% |
| CTAAACTTGAAAGCAATTTC+AGG | + | tig0049574:161-180 | Msa1467010:intergenic | 30.0% | |
| !! | CTGAAATTGCTTTCAAGTTT+AGG | - | tig0049574:159-178 | Msa1467010:intron | 30.0% |
| ! | TTGAGGGATTTAGATTTTGA+TGG | + | tig0049574:664-683 | Msa1467010:intergenic | 30.0% |
| ACTCATAAAGTAGGGTAAAA+TGG | + | tig0049574:749-768 | Msa1467010:intergenic | 30.0% | |
| AAAAGGACAAGCTGAAATTT+GGG | + | tig0049574:970-989 | Msa1467010:intergenic | 30.0% | |
| AAAAAGGACAAGCTGAAATT+TGG | + | tig0049574:971-990 | Msa1467010:intergenic | 30.0% | |
| CTAAACTTGAAAGCAATTTC+AGG | + | tig0049574:161-180 | Msa1467010:intergenic | 30.0% | |
| !! | CTGAAATTGCTTTCAAGTTT+AGG | - | tig0049574:159-178 | Msa1467010:intron | 30.0% |
| ! | TTGAGGGATTTAGATTTTGA+TGG | + | tig0049574:664-683 | Msa1467010:intergenic | 30.0% |
| ACTCATAAAGTAGGGTAAAA+TGG | + | tig0049574:749-768 | Msa1467010:intergenic | 30.0% | |
| AAAAGGACAAGCTGAAATTT+GGG | + | tig0049574:970-989 | Msa1467010:intergenic | 30.0% | |
| AAAAAGGACAAGCTGAAATT+TGG | + | tig0049574:971-990 | Msa1467010:intergenic | 30.0% | |
| ! | TTGTACGGCTTGAAATTTTC+TGG | + | tig0049574:41-60 | Msa0565270:intergenic | 35.0% |
| !! | GTCTCTTCATTTGACTTGTA+CGG | + | tig0049574:56-75 | Msa0565270:intergenic | 35.0% |
| ! | TTCAAATCAGCTTTTCCAAG+AGG | - | tig0049574:98-117 | Msa1467010:CDS | 35.0% |
| ! | TCAAATCAGCTTTTCCAAGA+GGG | - | tig0049574:99-118 | Msa1467010:CDS | 35.0% |
| AACTTGAAAGCAATTTCAGG+TGG | + | tig0049574:158-177 | Msa1467010:intergenic | 35.0% | |
| !! | TTGCTTTCAAGTTTAGGCAT+TGG | - | tig0049574:165-184 | Msa1467010:intron | 35.0% |
| !! | TGCTTTCAAGTTTAGGCATT+GGG | - | tig0049574:166-185 | Msa1467010:intron | 35.0% |
| !! | ATTTTTCGAAGGTCCTTTCA+AGG | - | tig0049574:190-209 | Msa1467010:intron | 35.0% |
| !! | TTTTTCGAAGGTCCTTTCAA+GGG | - | tig0049574:191-210 | Msa1467010:intron | 35.0% |
| !! | ATTTGAGTTTTGTCACCTTG+AGG | - | tig0049574:553-572 | Msa1467010:intron | 35.0% |
| ATGAAGTGTGAACTACTTAG+AGG | + | tig0049574:585-604 | Msa1467010:intergenic | 35.0% | |
| TCTAAGTAGTTCACACTTCA+TGG | - | tig0049574:584-603 | Msa1467010:intron | 35.0% | |
| ! | TTGTACGGCTTGAAATTTTC+TGG | + | tig0049574:41-60 | Msa1467010:intergenic | 35.0% |
| !! | GTCTCTTCATTTGACTTGTA+CGG | + | tig0049574:56-75 | Msa1467010:intergenic | 35.0% |
| ! | TTCAAATCAGCTTTTCCAAG+AGG | - | tig0049574:98-117 | Msa1467010:CDS | 35.0% |
| ! | TCAAATCAGCTTTTCCAAGA+GGG | - | tig0049574:99-118 | Msa1467010:CDS | 35.0% |
| AACTTGAAAGCAATTTCAGG+TGG | + | tig0049574:158-177 | Msa1467010:intergenic | 35.0% | |
| !! | TTGCTTTCAAGTTTAGGCAT+TGG | - | tig0049574:165-184 | Msa1467010:intron | 35.0% |
| !! | TGCTTTCAAGTTTAGGCATT+GGG | - | tig0049574:166-185 | Msa1467010:intron | 35.0% |
| !! | ATTTTTCGAAGGTCCTTTCA+AGG | - | tig0049574:190-209 | Msa1467010:intron | 35.0% |
| !! | TTTTTCGAAGGTCCTTTCAA+GGG | - | tig0049574:191-210 | Msa1467010:intron | 35.0% |
| !! | ATTTGAGTTTTGTCACCTTG+AGG | - | tig0049574:553-572 | Msa1467010:intron | 35.0% |
| ATGAAGTGTGAACTACTTAG+AGG | + | tig0049574:585-604 | Msa1467010:intergenic | 35.0% | |
| TCTAAGTAGTTCACACTTCA+TGG | - | tig0049574:584-603 | Msa1467010:intron | 35.0% | |
| ! | TTTTCCAAGAGGGTTTGCAT+GGG | - | tig0049574:109-128 | Msa1467010:intron | 40.0% |
| !! | GCTTTCAAGTTTAGGCATTG+GGG | - | tig0049574:167-186 | Msa1467010:intron | 40.0% |
| ATGGTCCAATTCTTTGGTCT+GGG | - | tig0049574:233-252 | Msa1467010:intron | 40.0% | |
| ATAGGTGGATGATGCTTTGA+AGG | - | tig0049574:875-894 | Msa1467010:CDS | 40.0% | |
| !! | TGATGCTTTGAAGGTTGAAG+AGG | - | tig0049574:884-903 | Msa1467010:CDS | 40.0% |
| ! | TGCTATCTCCACTTGTTAGA+AGG | + | tig0049574:947-966 | Msa1467010:intergenic | 40.0% |
| ! | TTTTCCAAGAGGGTTTGCAT+GGG | - | tig0049574:109-128 | Msa1467010:intron | 40.0% |
| !! | GCTTTCAAGTTTAGGCATTG+GGG | - | tig0049574:167-186 | Msa1467010:intron | 40.0% |
| ATGGTCCAATTCTTTGGTCT+GGG | - | tig0049574:233-252 | Msa1467010:intron | 40.0% | |
| ATAGGTGGATGATGCTTTGA+AGG | - | tig0049574:875-894 | Msa1467010:CDS | 40.0% | |
| !! | TGATGCTTTGAAGGTTGAAG+AGG | - | tig0049574:884-903 | Msa1467010:CDS | 40.0% |
| ! | TGCTATCTCCACTTGTTAGA+AGG | + | tig0049574:947-966 | Msa1467010:intergenic | 40.0% |
| ! | CTTTTCCAAGAGGGTTTGCA+TGG | - | tig0049574:108-127 | Msa1467010:intron | 45.0% |
| !!! | AGGCATTGGGGATTTTTCGA+AGG | - | tig0049574:179-198 | Msa1467010:intron | 45.0% |
| ATTGGACCATCTTCCCAGTA+GGG | + | tig0049574:223-242 | Msa1467010:intergenic | 45.0% | |
| AATTGGACCATCTTCCCAGT+AGG | + | tig0049574:224-243 | Msa1467010:intergenic | 45.0% | |
| GGGAAGATGGTCCAATTCTT+TGG | - | tig0049574:227-246 | Msa1467010:intron | 45.0% | |
| GATGGTCCAATTCTTTGGTC+TGG | - | tig0049574:232-251 | Msa1467010:intron | 45.0% | |
| GAGTTCCCAGACCAAAGAAT+TGG | + | tig0049574:241-260 | Msa1467010:intergenic | 45.0% | |
| !! | ACTTAGAGGTGTTGACCTCA+AGG | + | tig0049574:571-590 | Msa1467010:intergenic | 45.0% |
| ! | CTTTTCCAAGAGGGTTTGCA+TGG | - | tig0049574:108-127 | Msa1467010:intron | 45.0% |
| !!! | AGGCATTGGGGATTTTTCGA+AGG | - | tig0049574:179-198 | Msa1467010:intron | 45.0% |
| ATTGGACCATCTTCCCAGTA+GGG | + | tig0049574:223-242 | Msa1467010:intergenic | 45.0% | |
| AATTGGACCATCTTCCCAGT+AGG | + | tig0049574:224-243 | Msa1467010:intergenic | 45.0% | |
| GGGAAGATGGTCCAATTCTT+TGG | - | tig0049574:227-246 | Msa1467010:intron | 45.0% | |
| GATGGTCCAATTCTTTGGTC+TGG | - | tig0049574:232-251 | Msa1467010:intron | 45.0% | |
| GAGTTCCCAGACCAAAGAAT+TGG | + | tig0049574:241-260 | Msa1467010:intergenic | 45.0% | |
| !! | ACTTAGAGGTGTTGACCTCA+AGG | + | tig0049574:571-590 | Msa1467010:intergenic | 45.0% |
| ACTTCCCATGCAAACCCTCT+TGG | + | tig0049574:116-135 | Msa1467010:intergenic | 50.0% | |
| GTAGGGGAATGTCCCTTGAA+AGG | + | tig0049574:206-225 | Msa1467010:intergenic | 50.0% | |
| TTCAAGGGACATTCCCCTAC+TGG | - | tig0049574:206-225 | Msa1467010:intron | 50.0% | |
| TCAAGGGACATTCCCCTACT+GGG | - | tig0049574:207-226 | Msa1467010:intron | 50.0% | |
| ACATTCCCCTACTGGGAAGA+TGG | - | tig0049574:214-233 | Msa1467010:intron | 50.0% | |
| TTGGACCATCTTCCCAGTAG+GGG | + | tig0049574:222-241 | Msa1467010:intergenic | 50.0% | |
| CTTTGGTCTGGGAACTCTCA+AGG | - | tig0049574:244-263 | Msa1467010:intron | 50.0% | |
| TATGACCCAGCAGAGTTGCT+TGG | - | tig0049574:918-937 | Msa1467010:CDS | 50.0% | |
| CTTGGAGGCCTTCTAACAAG+TGG | - | tig0049574:936-955 | Msa1467010:CDS | 50.0% | |
| ACTTCCCATGCAAACCCTCT+TGG | + | tig0049574:116-135 | Msa1467010:intergenic | 50.0% | |
| GTAGGGGAATGTCCCTTGAA+AGG | + | tig0049574:206-225 | Msa1467010:intergenic | 50.0% | |
| TTCAAGGGACATTCCCCTAC+TGG | - | tig0049574:206-225 | Msa1467010:intron | 50.0% | |
| TCAAGGGACATTCCCCTACT+GGG | - | tig0049574:207-226 | Msa1467010:intron | 50.0% | |
| ACATTCCCCTACTGGGAAGA+TGG | - | tig0049574:214-233 | Msa1467010:intron | 50.0% | |
| TTGGACCATCTTCCCAGTAG+GGG | + | tig0049574:222-241 | Msa1467010:intergenic | 50.0% | |
| CTTTGGTCTGGGAACTCTCA+AGG | - | tig0049574:244-263 | Msa1467010:intron | 50.0% | |
| TATGACCCAGCAGAGTTGCT+TGG | - | tig0049574:918-937 | Msa1467010:CDS | 50.0% | |
| CTTGGAGGCCTTCTAACAAG+TGG | - | tig0049574:936-955 | Msa1467010:CDS | 50.0% | |
| GACCCAGCAGAGTTGCTTGG+AGG | - | tig0049574:921-940 | Msa1467010:CDS | 60.0% | |
| GGCCTCCAAGCAACTCTGCT+GGG | + | tig0049574:926-945 | Msa1467010:intergenic | 60.0% | |
| AGGCCTCCAAGCAACTCTGC+TGG | + | tig0049574:927-946 | Msa1467010:intergenic | 60.0% | |
| GACCCAGCAGAGTTGCTTGG+AGG | - | tig0049574:921-940 | Msa1467010:CDS | 60.0% | |
| GGCCTCCAAGCAACTCTGCT+GGG | + | tig0049574:926-945 | Msa1467010:intergenic | 60.0% | |
| AGGCCTCCAAGCAACTCTGC+TGG | + | tig0049574:927-946 | Msa1467010:intergenic | 60.0% |
| Chromosome | Type | Strat | End | Strand | Name |
|---|---|---|---|---|---|
| tig0049574 | gene | 2 | 998 | 2 | ID=Msa1467010;Name=Msa1467010 |
| tig0049574 | mRNA | 2 | 998 | 2 | ID=Msa1467010-mRNA-1;Parent=Msa1467010;Name=Msa1467010-mRNA-1;_AED=0.04;_eAED=0.04;_QI=0|0|0|1|1|1|2|0|127 |
| tig0049574 | exon | 735 | 998 | 735 | ID=Msa1467010-mRNA-1:exon:25183;Parent=Msa1467010-mRNA-1 |
| tig0049574 | exon | 2 | 121 | 2 | ID=Msa1467010-mRNA-1:exon:25182;Parent=Msa1467010-mRNA-1 |
| tig0049574 | CDS | 735 | 998 | 735 | ID=Msa1467010-mRNA-1:cds;Parent=Msa1467010-mRNA-1 |
| tig0049574 | CDS | 2 | 121 | 2 | ID=Msa1467010-mRNA-1:cds;Parent=Msa1467010-mRNA-1 |
| Gene Sequence |
| Protein sequence |