Alfalfa Gene Editing Database
Nr:
Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
---|---|---|---|---|---|---|---|---|---|---|---|
MS.gene013115.t1 | XP_003602855.1 | 87.5 | 104 | 13 | 0 | 1 | 104 | 17 | 120 | 8.20E-47 | 196.8 |
Swissprot:
Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
---|---|---|---|---|---|---|---|---|---|---|---|
MS.gene013115.t1 | Q41001 | 71.7 | 106 | 29 | 1 | 1 | 106 | 18 | 122 | 3.5e-38 | 159.5 |
Trembl:
Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
---|---|---|---|---|---|---|---|---|---|---|---|
MS.gene013115.t1 | G7J4J7 | 86.7 | 105 | 14 | 0 | 1 | 105 | 17 | 121 | 5.9e-47 | 196.8 |
TFs/TRs:
Gene ID | Type | Classification |
---|
Protein Kinases:
Gene ID | Type | Classification |
---|
Network:
Co-expression Network:
Gene1 | Gene2 | correlation coefficient | p_value | FDR |
---|
PPI:
Gene1 | Gene2 | Type |
---|---|---|
MS.gene013115 | MS.gene55509 | PPI |
MS.gene074086 | MS.gene013115 | PPI |
MS.gene47150 | MS.gene013115 | PPI |
Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
---|---|---|---|---|---|---|---|---|---|---|---|
MS.gene013115.t1 | MTR_3g099680 | 57.277 | 213 | 42 | 4 | 1 | 174 | 17 | 219 | 1.21e-66 | 203 |
MS.gene013115.t1 | MTR_3g099980 | 57.346 | 211 | 43 | 4 | 1 | 174 | 17 | 217 | 8.82e-66 | 201 |
MS.gene013115.t1 | MTR_3g099570 | 65.730 | 178 | 47 | 7 | 1 | 174 | 17 | 184 | 4.83e-62 | 190 |
MS.gene013115.t1 | MTR_3g099580 | 65.730 | 178 | 49 | 5 | 1 | 174 | 17 | 186 | 3.54e-57 | 177 |
MS.gene013115.t1 | MTR_3g099540 | 60.345 | 116 | 44 | 2 | 1 | 116 | 18 | 131 | 6.96e-39 | 129 |
MS.gene013115.t1 | MTR_8g007020 | 46.951 | 164 | 74 | 5 | 12 | 169 | 26 | 182 | 5.06e-33 | 116 |
MS.gene013115.t1 | MTR_8g007035 | 56.566 | 99 | 41 | 2 | 12 | 109 | 26 | 123 | 1.68e-30 | 110 |
MS.gene013115.t1 | MTR_4g114870 | 46.610 | 118 | 58 | 2 | 8 | 121 | 27 | 143 | 1.23e-27 | 106 |
MS.gene013115.t1 | MTR_4g114870 | 47.525 | 101 | 48 | 2 | 10 | 106 | 191 | 290 | 2.55e-25 | 100 |
MS.gene013115.t1 | MTR_5g006040 | 39.496 | 119 | 69 | 2 | 5 | 121 | 21 | 138 | 5.11e-27 | 100 |
MS.gene013115.t1 | MTR_1g090190 | 38.983 | 118 | 70 | 2 | 8 | 125 | 21 | 136 | 5.93e-27 | 100 |
MS.gene013115.t1 | MTR_7g086140 | 43.000 | 100 | 57 | 0 | 10 | 109 | 26 | 125 | 2.63e-23 | 90.5 |
MS.gene013115.t1 | MTR_7g086190 | 43.000 | 100 | 57 | 0 | 10 | 109 | 26 | 125 | 2.63e-23 | 90.5 |
MS.gene013115.t1 | MTR_7g086160 | 41.748 | 103 | 60 | 0 | 7 | 109 | 24 | 126 | 3.03e-22 | 87.8 |
MS.gene013115.t1 | MTR_1g105130 | 42.268 | 97 | 56 | 0 | 10 | 106 | 25 | 121 | 3.63e-22 | 87.4 |
MS.gene013115.t1 | MTR_1g105120 | 42.268 | 97 | 56 | 0 | 10 | 106 | 25 | 121 | 3.63e-22 | 87.4 |
MS.gene013115.t1 | MTR_8g099220 | 42.718 | 103 | 55 | 2 | 8 | 107 | 27 | 128 | 8.63e-22 | 85.9 |
MS.gene013115.t1 | MTR_6g080660 | 46.154 | 104 | 54 | 2 | 7 | 110 | 25 | 126 | 8.64e-22 | 87.8 |
MS.gene013115.t1 | MTR_1g104800 | 40.000 | 100 | 57 | 2 | 9 | 106 | 24 | 122 | 2.18e-21 | 86.3 |
MS.gene013115.t1 | MTR_2g088990 | 39.259 | 135 | 72 | 5 | 7 | 139 | 22 | 148 | 3.67e-21 | 86.7 |
MS.gene013115.t1 | MTR_6g083240 | 33.537 | 164 | 82 | 5 | 12 | 169 | 29 | 171 | 3.86e-21 | 85.5 |
MS.gene013115.t1 | MTR_1g112700 | 38.318 | 107 | 64 | 2 | 8 | 113 | 31 | 136 | 5.42e-21 | 85.1 |
MS.gene013115.t1 | MTR_7g086220 | 40.000 | 100 | 60 | 0 | 10 | 109 | 25 | 124 | 6.71e-21 | 84.3 |
MS.gene013115.t1 | MTR_0334s0010 | 41.121 | 107 | 58 | 3 | 5 | 108 | 23 | 127 | 3.08e-19 | 80.9 |
MS.gene013115.t1 | MTR_4g067200 | 38.793 | 116 | 64 | 4 | 1 | 110 | 19 | 133 | 2.54e-18 | 78.2 |
MS.gene013115.t1 | MTR_4g066110 | 38.793 | 116 | 64 | 4 | 1 | 110 | 19 | 133 | 2.54e-18 | 78.2 |
MS.gene013115.t1 | MTR_2g025580 | 37.037 | 108 | 66 | 2 | 1 | 107 | 18 | 124 | 2.16e-17 | 75.5 |
MS.gene013115.t1 | MTR_6g023760 | 40.404 | 99 | 58 | 1 | 8 | 106 | 24 | 121 | 3.77e-17 | 75.1 |
MS.gene013115.t1 | MTR_3g089035 | 43.158 | 95 | 50 | 3 | 10 | 104 | 33 | 123 | 4.02e-17 | 73.6 |
MS.gene013115.t1 | MTR_2g083250 | 43.269 | 104 | 52 | 3 | 11 | 108 | 27 | 129 | 6.63e-17 | 75.9 |
MS.gene013115.t1 | MTR_4g114830 | 39.560 | 91 | 49 | 2 | 11 | 95 | 30 | 120 | 9.26e-17 | 73.6 |
MS.gene013115.t1 | MTR_7g086090 | 40.206 | 97 | 57 | 1 | 11 | 107 | 27 | 122 | 3.18e-16 | 73.9 |
MS.gene013115.t1 | MTR_2g043730 | 40.625 | 96 | 53 | 3 | 10 | 105 | 32 | 123 | 8.17e-16 | 70.1 |
MS.gene013115.t1 | MTR_1g090420 | 30.328 | 122 | 79 | 3 | 7 | 123 | 25 | 145 | 8.55e-16 | 72.4 |
MS.gene013115.t1 | MTR_7g086280 | 38.776 | 98 | 59 | 1 | 10 | 107 | 26 | 122 | 8.72e-16 | 71.2 |
MS.gene013115.t1 | MTR_7g086230 | 38.776 | 98 | 59 | 1 | 10 | 107 | 26 | 122 | 8.72e-16 | 71.2 |
MS.gene013115.t1 | MTR_6g013420 | 36.000 | 125 | 69 | 4 | 8 | 123 | 36 | 158 | 9.95e-16 | 71.2 |
MS.gene013115.t1 | MTR_8g463180 | 33.051 | 118 | 73 | 3 | 5 | 117 | 19 | 135 | 1.20e-15 | 73.2 |
MS.gene013115.t1 | MTR_4g081100 | 38.889 | 90 | 51 | 1 | 11 | 96 | 33 | 122 | 1.35e-15 | 72.0 |
MS.gene013115.t1 | MTR_2g101300 | 36.000 | 125 | 70 | 4 | 12 | 131 | 29 | 148 | 2.60e-15 | 70.5 |
MS.gene013115.t1 | MTR_8g086360 | 29.878 | 164 | 110 | 4 | 12 | 173 | 26 | 186 | 6.11e-15 | 69.7 |
MS.gene013115.t1 | MTR_7g086100 | 39.583 | 96 | 57 | 1 | 11 | 106 | 27 | 121 | 6.95e-15 | 70.1 |
MS.gene013115.t1 | MTR_4g007250 | 36.538 | 104 | 64 | 2 | 4 | 107 | 23 | 124 | 7.39e-15 | 68.9 |
MS.gene013115.t1 | MTR_8g088830 | 40.909 | 88 | 48 | 3 | 12 | 98 | 30 | 114 | 1.08e-14 | 67.4 |
MS.gene013115.t1 | MTR_6g013200 | 35.294 | 119 | 71 | 4 | 11 | 127 | 36 | 150 | 1.11e-14 | 68.6 |
MS.gene013115.t1 | MTR_2g043790 | 40.625 | 96 | 53 | 3 | 10 | 105 | 7 | 98 | 1.25e-14 | 66.6 |
MS.gene013115.t1 | MTR_8g089110 | 37.500 | 96 | 56 | 3 | 10 | 105 | 28 | 119 | 2.10e-13 | 63.9 |
MS.gene013115.t1 | MTR_3g089005 | 36.538 | 104 | 62 | 3 | 1 | 104 | 24 | 123 | 2.40e-13 | 63.9 |
MS.gene013115.t1 | MTR_4g130780 | 34.783 | 92 | 59 | 1 | 24 | 115 | 48 | 138 | 2.43e-13 | 65.1 |
MS.gene013115.t1 | MTR_4g130800 | 35.514 | 107 | 63 | 3 | 5 | 106 | 24 | 129 | 3.43e-13 | 65.9 |
MS.gene013115.t1 | MTR_8g094990 | 33.929 | 112 | 70 | 2 | 12 | 120 | 27 | 137 | 4.59e-13 | 65.9 |
MS.gene013115.t1 | MTR_4g077787 | 30.882 | 136 | 79 | 4 | 12 | 135 | 34 | 166 | 5.52e-13 | 64.3 |
MS.gene013115.t1 | MTR_7g086200 | 34.821 | 112 | 57 | 2 | 10 | 121 | 4 | 99 | 6.87e-13 | 62.4 |
MS.gene013115.t1 | MTR_4g130800 | 40.244 | 82 | 48 | 1 | 25 | 106 | 48 | 128 | 6.94e-13 | 65.1 |
MS.gene013115.t1 | MTR_4g124280 | 32.967 | 91 | 57 | 1 | 12 | 98 | 27 | 117 | 3.92e-12 | 62.8 |
MS.gene013115.t1 | MTR_6g022170 | 37.000 | 100 | 55 | 4 | 12 | 106 | 36 | 132 | 5.72e-12 | 61.2 |
MS.gene013115.t1 | MTR_2g090575 | 35.955 | 89 | 55 | 1 | 12 | 98 | 27 | 115 | 7.05e-12 | 62.8 |
MS.gene013115.t1 | MTR_2g090580 | 27.907 | 172 | 114 | 5 | 12 | 173 | 29 | 200 | 1.18e-11 | 60.8 |
MS.gene013115.t1 | MTR_4g111640 | 30.147 | 136 | 80 | 4 | 12 | 135 | 34 | 166 | 1.59e-11 | 60.1 |
MS.gene013115.t1 | MTR_6g013170 | 30.201 | 149 | 94 | 5 | 9 | 156 | 30 | 169 | 3.20e-11 | 59.3 |
MS.gene013115.t1 | MTR_4g078410 | 29.134 | 127 | 87 | 2 | 12 | 136 | 27 | 152 | 3.40e-11 | 59.3 |
MS.gene013115.t1 | MTR_1g014120 | 34.066 | 91 | 59 | 1 | 25 | 115 | 45 | 134 | 5.60e-11 | 58.9 |
MS.gene013115.t1 | MTR_3g105930 | 31.132 | 106 | 69 | 2 | 25 | 127 | 47 | 151 | 5.72e-11 | 58.5 |
Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
---|---|---|---|---|---|---|---|---|---|---|---|
MS.gene013115.t1 | AT1G72230 | 54.386 | 114 | 44 | 3 | 18 | 131 | 31 | 136 | 2.86e-34 | 119 |
MS.gene013115.t1 | AT1G22480 | 55.670 | 97 | 41 | 2 | 16 | 112 | 25 | 119 | 1.59e-27 | 102 |
MS.gene013115.t1 | AT2G32300 | 40.909 | 132 | 71 | 3 | 5 | 131 | 21 | 150 | 1.80e-25 | 99.0 |
MS.gene013115.t1 | AT2G32300 | 40.909 | 132 | 71 | 3 | 5 | 131 | 51 | 180 | 3.47e-25 | 98.6 |
MS.gene013115.t1 | AT5G07475 | 38.636 | 132 | 69 | 3 | 8 | 129 | 28 | 157 | 3.89e-25 | 96.3 |
MS.gene013115.t1 | AT2G31050 | 45.299 | 117 | 60 | 3 | 7 | 122 | 26 | 139 | 1.84e-24 | 94.7 |
MS.gene013115.t1 | AT3G17675 | 40.566 | 106 | 62 | 1 | 1 | 106 | 23 | 127 | 1.25e-23 | 90.5 |
MS.gene013115.t1 | AT2G26720 | 40.351 | 114 | 66 | 2 | 7 | 119 | 26 | 138 | 2.81e-23 | 91.7 |
MS.gene013115.t1 | AT5G26330 | 41.284 | 109 | 61 | 2 | 5 | 110 | 19 | 127 | 7.40e-23 | 90.1 |
MS.gene013115.t1 | AT2G44790 | 49.474 | 95 | 46 | 2 | 18 | 111 | 36 | 129 | 2.91e-21 | 86.7 |
MS.gene013115.t1 | AT3G60270 | 47.959 | 98 | 49 | 2 | 12 | 109 | 28 | 123 | 4.37e-21 | 85.5 |
MS.gene013115.t1 | AT3G27200 | 41.837 | 98 | 54 | 3 | 10 | 106 | 26 | 121 | 4.84e-19 | 80.1 |
MS.gene013115.t1 | AT5G20230 | 41.463 | 123 | 66 | 3 | 12 | 131 | 27 | 146 | 2.67e-18 | 78.6 |
MS.gene013115.t1 | AT3G60280 | 42.857 | 98 | 54 | 2 | 12 | 109 | 26 | 121 | 8.77e-16 | 72.4 |
MS.gene013115.t1 | AT1G64640 | 35.772 | 123 | 74 | 3 | 8 | 127 | 31 | 151 | 1.80e-14 | 68.2 |
MS.gene013115.t1 | AT4G28365 | 28.249 | 177 | 118 | 3 | 5 | 173 | 24 | 199 | 1.36e-13 | 66.2 |
MS.gene013115.t1 | AT5G53870 | 30.909 | 110 | 74 | 1 | 12 | 119 | 32 | 141 | 1.38e-13 | 67.8 |
MS.gene013115.t1 | AT2G25060 | 38.542 | 96 | 55 | 2 | 24 | 116 | 50 | 144 | 1.53e-13 | 65.9 |
MS.gene013115.t1 | AT5G53870 | 30.909 | 110 | 74 | 1 | 12 | 119 | 32 | 141 | 1.80e-13 | 67.4 |
MS.gene013115.t1 | AT5G15350 | 33.333 | 132 | 79 | 5 | 1 | 127 | 17 | 144 | 3.16e-13 | 64.7 |
MS.gene013115.t1 | AT2G02850 | 38.384 | 99 | 57 | 3 | 6 | 104 | 32 | 126 | 3.89e-13 | 63.5 |
MS.gene013115.t1 | AT3G01070 | 33.333 | 117 | 77 | 1 | 12 | 127 | 29 | 145 | 1.82e-12 | 62.4 |
MS.gene013115.t1 | AT4G27520 | 34.021 | 97 | 61 | 2 | 12 | 106 | 33 | 128 | 2.20e-12 | 64.3 |
MS.gene013115.t1 | AT4G31840 | 30.693 | 101 | 70 | 0 | 24 | 124 | 46 | 146 | 7.14e-12 | 61.2 |
MS.gene013115.t1 | AT3G20570 | 30.769 | 156 | 97 | 3 | 12 | 157 | 32 | 186 | 1.26e-11 | 60.8 |
MS.gene013115.t1 | AT4G30590 | 32.520 | 123 | 77 | 4 | 9 | 126 | 27 | 148 | 8.79e-11 | 58.5 |
Find 0 sgRNAs with CRISPR-Local
Find 48 sgRNAs with CRISPR-GE
CRISPR-Local
sgRNA_sequence | on_target_score | Position | Region |
---|
CRISPR-GE
badsite warning | sgRNA_sequence | Strand | Position | Region | GC_content |
---|---|---|---|---|---|
! | TGATTCTGATTATACAACAT+GGG | - | 23849:28841-28860 | MS.gene013115:CDS | 25.0% |
! | TTGATTCTGATTATACAACA+TGG | - | 23849:28840-28859 | MS.gene013115:CDS | 25.0% |
ACGAAAAATAAACCAACGAT+TGG | + | 23849:29348-29367 | None:intergenic | 30.0% | |
TCAATTAGTACAGATAGTAG+TGG | - | 23849:29069-29088 | MS.gene013115:CDS | 30.0% | |
ACAGTGTTCAATTATGAAGC+TGG | - | 23849:28988-29007 | MS.gene013115:CDS | 35.0% | |
AGTGACAAAACCTTTGTAGT+TGG | - | 23849:28866-28885 | MS.gene013115:CDS | 35.0% | |
CAGTGTTCAATTATGAAGCT+GGG | - | 23849:28989-29008 | MS.gene013115:CDS | 35.0% | |
GAAACTCTCTGTTAAGGTTA+AGG | - | 23849:29173-29192 | MS.gene013115:intron | 35.0% | |
! | AGTTGAAGATGCATTTTGCA+TGG | + | 23849:29316-29335 | None:intergenic | 35.0% |
!!! | AATGAGTTCCTACTTTTTCG+AGG | + | 23849:29110-29129 | None:intergenic | 35.0% |
!!! | ATGAGTTCCTACTTTTTCGA+GGG | + | 23849:29109-29128 | None:intergenic | 35.0% |
GGGTGCAATAGTAATTGTGT+CGG | + | 23849:29268-29287 | None:intergenic | 40.0% | |
GGTGCAATAGTAATTGTGTC+GGG | + | 23849:29267-29286 | None:intergenic | 40.0% | |
GTGCAATAGTAATTGTGTCG+GGG | + | 23849:29266-29285 | None:intergenic | 40.0% | |
GTTCCTGTACATTGCATAAG+TGG | - | 23849:29144-29163 | MS.gene013115:CDS | 40.0% | |
TGCAATAGTAATTGTGTCGG+GGG | + | 23849:29265-29284 | None:intergenic | 40.0% | |
TGGCATGAAACTCTCTGTTA+AGG | - | 23849:29167-29186 | MS.gene013115:CDS | 40.0% | |
TGTTCAATTATGAAGCTGGG+TGG | - | 23849:28992-29011 | MS.gene013115:CDS | 40.0% | |
! | GAAGATGCATTTTGCATGGT+AGG | + | 23849:29312-29331 | None:intergenic | 40.0% |
! | TTGTTGGAGATGCTTTAGGT+TGG | - | 23849:28813-28832 | MS.gene013115:CDS | 40.0% |
!! | TTTGTAGTTGGTGACAGTCT+CGG | - | 23849:28878-28897 | MS.gene013115:CDS | 40.0% |
!!! | TGAGTTCCTACTTTTTCGAG+GGG | + | 23849:29108-29127 | None:intergenic | 40.0% |
ACCATTCCCCTCGAAAAAGT+AGG | - | 23849:29099-29118 | MS.gene013115:CDS | 45.0% | |
CACGTTGTTGGAGATGCTTT+AGG | - | 23849:28809-28828 | MS.gene013115:CDS | 45.0% | |
CCACCACTTATGCAATGTAC+AGG | + | 23849:29150-29169 | None:intergenic | 45.0% | |
CCTGTACATTGCATAAGTGG+TGG | - | 23849:29147-29166 | MS.gene013115:CDS | 45.0% | |
GAGACTGTCACCAACTACAA+AGG | + | 23849:28879-28898 | None:intergenic | 45.0% | |
GGGAAAGGTTCACCTTCTAA+TGG | - | 23849:29237-29256 | MS.gene013115:intron | 45.0% | |
TTGCATGGTAGGAGTAGCAA+TGG | + | 23849:29301-29320 | None:intergenic | 45.0% | |
! | ACTAGTCTCTCACCAATCGT+TGG | - | 23849:29333-29352 | MS.gene013115:CDS | 45.0% |
! | CTAAAGCATCTCCAACAACG+TGG | + | 23849:28811-28830 | None:intergenic | 45.0% |
!!! | TCCTACTTTTTCGAGGGGAA+TGG | + | 23849:29103-29122 | None:intergenic | 45.0% |
!!! | TTTTTCGAGGGGAATGGTTG+TGG | + | 23849:29097-29116 | None:intergenic | 45.0% |
CATGGTAGGAGTAGCAATGG+TGG | + | 23849:29298-29317 | None:intergenic | 50.0% | |
CTTCAGCAACGCCATCATCA+GGG | - | 23849:29217-29236 | MS.gene013115:intron | 50.0% | |
GGTGAACCTTTCCCTGATGA+TGG | + | 23849:29231-29250 | None:intergenic | 50.0% | |
ACGTGGACAGTTCCCTGAGT+CGG | + | 23849:28794-28813 | None:intergenic | 55.0% | |
CAGGGAACTGTCCACGTTGT+TGG | - | 23849:28797-28816 | MS.gene013115:CDS | 55.0% | |
CCTTCAGCAACGCCATCATC+AGG | - | 23849:29216-29235 | MS.gene013115:intron | 55.0% | |
GCAACGCCATCATCAGGGAA+AGG | - | 23849:29222-29241 | MS.gene013115:intron | 55.0% | |
GGTAGGAGTAGCAATGGTGG+TGG | + | 23849:29295-29314 | None:intergenic | 55.0% | |
TGCTGAAGGAGCAGCAGAAG+CGG | + | 23849:29205-29224 | None:intergenic | 55.0% | |
!! | AGGAGTAGCAATGGTGGTGG+TGG | + | 23849:29292-29311 | None:intergenic | 55.0% |
!! | AGTAGCAATGGTGGTGGTGG+AGG | + | 23849:29289-29308 | None:intergenic | 55.0% |
!! | CCTGATGATGGCGTTGCTGA+AGG | + | 23849:29219-29238 | None:intergenic | 55.0% |
!! | GTAGCAATGGTGGTGGTGGA+GGG | + | 23849:29288-29307 | None:intergenic | 55.0% |
TGAAGCTGGGTGGCACACAG+TGG | - | 23849:29002-29021 | MS.gene013115:CDS | 60.0% | |
!! | GTGTCGGGGGTGCCATTAGA+AGG | + | 23849:29252-29271 | None:intergenic | 60.0% |
Chromosome | Type | Strat | End | Strand | Name |
---|---|---|---|---|---|
23849 | gene | 28782 | 29398 | 28782 | ID=MS.gene013115 |
23849 | mRNA | 28782 | 29398 | 28782 | ID=MS.gene013115.t1;Parent=MS.gene013115 |
23849 | exon | 29281 | 29398 | 29281 | ID=MS.gene013115.t1.exon1;Parent=MS.gene013115.t1 |
23849 | CDS | 29281 | 29398 | 29281 | ID=cds.MS.gene013115.t1;Parent=MS.gene013115.t1 |
23849 | exon | 28782 | 29188 | 28782 | ID=MS.gene013115.t1.exon2;Parent=MS.gene013115.t1 |
23849 | CDS | 28782 | 29188 | 28782 | ID=cds.MS.gene013115.t1;Parent=MS.gene013115.t1 |
Gene Sequence |
Protein sequence |