Alfalfa Gene Editing Database
Nr:
Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
---|---|---|---|---|---|---|---|---|---|---|---|
MS.gene61741.t1 | RHN51432.1 | 84.8 | 230 | 21 | 2 | 1 | 218 | 60 | 287 | 3.30E-93 | 351.3 |
Swissprot:
Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
---|---|---|---|---|---|---|---|---|---|---|---|
MS.gene61741.t1 | Q9T072 | 42.9 | 212 | 97 | 6 | 12 | 218 | 111 | 303 | 5.4e-28 | 125.9 |
Trembl:
Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
---|---|---|---|---|---|---|---|---|---|---|---|
MS.gene61741.t1 | A0A396HDM9 | 84.8 | 230 | 21 | 2 | 1 | 218 | 60 | 287 | 2.3e-93 | 351.3 |
TFs/TRs:
Gene ID | Type | Classification |
---|---|---|
MS.gene61741.t1 | TF | bHLH |
Protein Kinases:
Gene ID | Type | Classification |
---|
Network:
Co-expression Network:
Gene1 | Gene2 | correlation coefficient | p_value | FDR |
---|---|---|---|---|
MS.gene050520 | MS.gene61741 | 0.810219 | 1.29E-50 | -1.69E-46 |
MS.gene054196 | MS.gene61741 | 0.969332 | 5.75E-130 | -1.69E-46 |
MS.gene058183 | MS.gene61741 | 0.835576 | 1.55E-56 | -1.69E-46 |
MS.gene059034 | MS.gene61741 | 0.815206 | 1.04E-51 | -1.69E-46 |
MS.gene059367 | MS.gene61741 | 0.80303 | 4.23E-49 | -1.69E-46 |
MS.gene059680 | MS.gene61741 | 0.810239 | 1.27E-50 | -1.69E-46 |
MS.gene060482 | MS.gene61741 | 0.820481 | 6.70E-53 | -1.69E-46 |
PPI:
Gene1 | Gene2 | Type |
---|
Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
---|---|---|---|---|---|---|---|---|---|---|---|
MS.gene61741.t1 | MTR_6g047570 | 84.783 | 230 | 21 | 2 | 1 | 218 | 82 | 309 | 1.21e-136 | 386 |
MS.gene61741.t1 | MTR_0250s0040 | 74.208 | 221 | 50 | 3 | 2 | 218 | 21 | 238 | 1.30e-111 | 320 |
MS.gene61741.t1 | MTR_0011s0260 | 63.374 | 243 | 59 | 3 | 1 | 218 | 96 | 333 | 1.83e-97 | 288 |
MS.gene61741.t1 | MTR_0011s0210 | 62.140 | 243 | 62 | 3 | 1 | 218 | 96 | 333 | 1.45e-94 | 280 |
MS.gene61741.t1 | MTR_4g066460 | 61.570 | 242 | 51 | 4 | 6 | 218 | 74 | 302 | 3.76e-89 | 266 |
MS.gene61741.t1 | MTR_4g067010 | 62.115 | 227 | 57 | 6 | 6 | 218 | 83 | 294 | 3.34e-87 | 261 |
MS.gene61741.t1 | MTR_4g066380 | 64.035 | 228 | 57 | 5 | 6 | 218 | 82 | 299 | 3.95e-80 | 243 |
MS.gene61741.t1 | MTR_6g047550 | 79.487 | 156 | 15 | 4 | 1 | 141 | 94 | 247 | 1.32e-71 | 219 |
MS.gene61741.t1 | MTR_0246s0020 | 52.830 | 265 | 76 | 4 | 1 | 218 | 90 | 352 | 6.21e-68 | 213 |
MS.gene61741.t1 | MTR_0246s0020 | 52.830 | 265 | 76 | 4 | 1 | 218 | 90 | 352 | 8.08e-68 | 213 |
MS.gene61741.t1 | MTR_0246s0050 | 53.097 | 226 | 85 | 6 | 3 | 218 | 80 | 294 | 1.13e-63 | 200 |
MS.gene61741.t1 | MTR_4g098035 | 53.097 | 226 | 85 | 6 | 3 | 218 | 101 | 315 | 1.80e-63 | 201 |
MS.gene61741.t1 | MTR_5g014520 | 53.179 | 173 | 80 | 1 | 46 | 218 | 136 | 307 | 4.56e-51 | 168 |
MS.gene61741.t1 | MTR_5g014560 | 54.706 | 170 | 69 | 3 | 53 | 218 | 116 | 281 | 6.50e-51 | 167 |
MS.gene61741.t1 | MTR_4g009540 | 40.000 | 215 | 115 | 4 | 18 | 218 | 94 | 308 | 2.09e-42 | 145 |
MS.gene61741.t1 | MTR_4g009540 | 40.000 | 215 | 115 | 4 | 18 | 218 | 94 | 308 | 2.66e-42 | 145 |
MS.gene61741.t1 | MTR_5g014600 | 41.176 | 221 | 108 | 6 | 12 | 218 | 100 | 312 | 6.93e-41 | 142 |
MS.gene61741.t1 | MTR_4g092700 | 44.385 | 187 | 101 | 3 | 33 | 218 | 124 | 308 | 1.29e-38 | 136 |
MS.gene61741.t1 | MTR_4g097920 | 46.104 | 154 | 79 | 2 | 66 | 218 | 138 | 288 | 2.02e-38 | 135 |
MS.gene61741.t1 | MTR_4g097920 | 46.104 | 154 | 79 | 2 | 66 | 218 | 153 | 303 | 3.69e-38 | 135 |
MS.gene61741.t1 | MTR_4g009110 | 36.986 | 219 | 120 | 4 | 18 | 218 | 109 | 327 | 1.12e-37 | 134 |
MS.gene61741.t1 | MTR_4g097940 | 46.753 | 154 | 78 | 3 | 66 | 218 | 153 | 303 | 2.76e-37 | 132 |
MS.gene61741.t1 | MTR_2g010450 | 42.286 | 175 | 86 | 4 | 52 | 218 | 161 | 328 | 4.96e-36 | 130 |
MS.gene61741.t1 | MTR_5g014640 | 44.872 | 156 | 83 | 2 | 63 | 218 | 149 | 301 | 1.50e-35 | 128 |
MS.gene61741.t1 | MTR_2g104490 | 40.541 | 185 | 101 | 4 | 40 | 218 | 104 | 285 | 2.20e-35 | 127 |
MS.gene61741.t1 | MTR_2g104490 | 40.541 | 185 | 101 | 4 | 40 | 218 | 104 | 285 | 3.16e-35 | 127 |
MS.gene61741.t1 | MTR_4g097950 | 45.930 | 172 | 78 | 4 | 58 | 218 | 60 | 227 | 3.68e-35 | 125 |
MS.gene61741.t1 | MTR_2g104550 | 41.935 | 186 | 96 | 6 | 42 | 218 | 107 | 289 | 1.15e-34 | 125 |
MS.gene61741.t1 | MTR_8g009020 | 35.616 | 219 | 116 | 6 | 23 | 218 | 84 | 300 | 4.84e-31 | 116 |
MS.gene61741.t1 | MTR_8g069740 | 38.286 | 175 | 103 | 4 | 48 | 218 | 91 | 264 | 9.30e-31 | 114 |
MS.gene61741.t1 | MTR_7g080780 | 39.080 | 174 | 96 | 3 | 45 | 218 | 130 | 293 | 1.42e-30 | 115 |
MS.gene61741.t1 | MTR_7g080780 | 39.080 | 174 | 96 | 3 | 45 | 218 | 143 | 306 | 1.85e-30 | 115 |
MS.gene61741.t1 | MTR_2g104560 | 31.628 | 215 | 123 | 6 | 14 | 218 | 2 | 202 | 1.34e-28 | 107 |
MS.gene61741.t1 | MTR_5g014550 | 49.219 | 128 | 51 | 4 | 98 | 218 | 54 | 174 | 9.21e-27 | 102 |
MS.gene61741.t1 | MTR_8g009010 | 33.803 | 213 | 87 | 5 | 24 | 218 | 73 | 249 | 1.24e-25 | 102 |
MS.gene61741.t1 | MTR_2g104650 | 39.000 | 200 | 99 | 6 | 31 | 218 | 58 | 246 | 1.75e-25 | 100 |
MS.gene61741.t1 | MTR_2g104500 | 34.742 | 213 | 119 | 6 | 17 | 218 | 46 | 249 | 1.08e-23 | 95.9 |
MS.gene61741.t1 | MTR_2g104530 | 37.333 | 150 | 90 | 1 | 69 | 218 | 106 | 251 | 6.17e-23 | 94.0 |
MS.gene61741.t1 | MTR_2g104590 | 31.050 | 219 | 122 | 6 | 6 | 218 | 6 | 201 | 1.13e-20 | 87.0 |
MS.gene61741.t1 | MTR_1g072320 | 33.103 | 145 | 83 | 3 | 68 | 201 | 470 | 611 | 2.52e-17 | 80.5 |
MS.gene61741.t1 | MTR_8g067280 | 34.868 | 152 | 80 | 4 | 68 | 204 | 462 | 609 | 3.60e-16 | 77.0 |
MS.gene61741.t1 | MTR_8g024790 | 30.405 | 148 | 84 | 5 | 61 | 197 | 284 | 423 | 1.92e-15 | 74.7 |
MS.gene61741.t1 | MTR_4g009510 | 33.108 | 148 | 73 | 6 | 79 | 218 | 53 | 182 | 3.17e-14 | 68.9 |
MS.gene61741.t1 | MTR_5g030430 | 29.054 | 148 | 94 | 1 | 68 | 204 | 493 | 640 | 3.77e-14 | 71.2 |
MS.gene61741.t1 | MTR_8g064700 | 26.471 | 204 | 133 | 7 | 24 | 217 | 202 | 398 | 5.16e-14 | 70.5 |
MS.gene61741.t1 | MTR_4g009420 | 32.812 | 128 | 68 | 3 | 91 | 218 | 65 | 174 | 5.67e-14 | 68.2 |
MS.gene61741.t1 | MTR_8g027495 | 50.000 | 64 | 32 | 0 | 68 | 131 | 458 | 521 | 1.03e-13 | 69.7 |
MS.gene61741.t1 | MTR_7g451650 | 32.593 | 135 | 67 | 4 | 91 | 218 | 57 | 174 | 1.07e-13 | 67.4 |
MS.gene61741.t1 | MTR_4g009420 | 32.812 | 128 | 68 | 3 | 91 | 218 | 65 | 174 | 1.15e-13 | 67.4 |
MS.gene61741.t1 | MTR_7g451650 | 32.593 | 135 | 67 | 4 | 91 | 218 | 57 | 174 | 1.49e-13 | 67.0 |
MS.gene61741.t1 | MTR_8g098275 | 41.250 | 80 | 47 | 0 | 52 | 131 | 385 | 464 | 1.58e-13 | 69.3 |
MS.gene61741.t1 | MTR_8g098275 | 41.250 | 80 | 47 | 0 | 52 | 131 | 292 | 371 | 1.67e-13 | 68.9 |
MS.gene61741.t1 | MTR_8g098275 | 41.250 | 80 | 47 | 0 | 52 | 131 | 228 | 307 | 1.87e-13 | 68.9 |
MS.gene61741.t1 | MTR_7g117670 | 46.667 | 75 | 36 | 2 | 68 | 142 | 402 | 472 | 4.17e-13 | 68.2 |
MS.gene61741.t1 | MTR_8g024770 | 31.507 | 146 | 84 | 5 | 44 | 177 | 251 | 392 | 8.97e-13 | 67.0 |
MS.gene61741.t1 | MTR_3g498695 | 30.818 | 159 | 94 | 3 | 69 | 214 | 299 | 454 | 2.06e-12 | 65.9 |
MS.gene61741.t1 | MTR_3g498695 | 30.818 | 159 | 94 | 3 | 69 | 214 | 299 | 454 | 2.09e-12 | 65.9 |
MS.gene61741.t1 | MTR_3g030700 | 30.000 | 150 | 100 | 2 | 70 | 214 | 198 | 347 | 4.53e-12 | 64.7 |
MS.gene61741.t1 | MTR_1g112680 | 31.214 | 173 | 88 | 7 | 47 | 189 | 295 | 466 | 4.70e-12 | 64.7 |
MS.gene61741.t1 | MTR_7g050350 | 31.008 | 129 | 65 | 4 | 97 | 218 | 1 | 112 | 5.61e-12 | 61.6 |
MS.gene61741.t1 | MTR_7g451650 | 31.008 | 129 | 65 | 4 | 97 | 218 | 1 | 112 | 5.61e-12 | 61.6 |
MS.gene61741.t1 | MTR_7g096350 | 50.000 | 54 | 27 | 0 | 68 | 121 | 355 | 408 | 1.67e-11 | 63.2 |
Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
---|---|---|---|---|---|---|---|---|---|---|---|
MS.gene61741.t1 | AT4G37850 | 42.925 | 212 | 97 | 6 | 12 | 218 | 111 | 303 | 1.14e-40 | 141 |
MS.gene61741.t1 | AT4G37850 | 42.925 | 212 | 97 | 6 | 12 | 218 | 111 | 303 | 1.14e-40 | 141 |
MS.gene61741.t1 | AT2G22750 | 45.349 | 172 | 86 | 3 | 53 | 218 | 111 | 280 | 1.89e-33 | 122 |
MS.gene61741.t1 | AT2G22750 | 45.349 | 172 | 86 | 3 | 53 | 218 | 111 | 280 | 1.93e-33 | 122 |
MS.gene61741.t1 | AT2G22750 | 45.349 | 172 | 86 | 3 | 53 | 218 | 139 | 308 | 2.50e-33 | 122 |
MS.gene61741.t1 | AT2G22750 | 45.349 | 172 | 86 | 3 | 53 | 218 | 139 | 308 | 2.84e-33 | 122 |
MS.gene61741.t1 | AT2G22750 | 45.349 | 172 | 86 | 3 | 53 | 218 | 135 | 304 | 3.04e-33 | 122 |
MS.gene61741.t1 | AT2G22760 | 40.698 | 172 | 90 | 4 | 58 | 218 | 102 | 272 | 9.46e-33 | 120 |
MS.gene61741.t1 | AT2G22760 | 40.698 | 172 | 90 | 4 | 58 | 218 | 102 | 272 | 1.02e-32 | 119 |
MS.gene61741.t1 | AT2G22770 | 35.160 | 219 | 117 | 5 | 17 | 218 | 87 | 297 | 1.16e-29 | 112 |
MS.gene61741.t1 | AT4G17880 | 35.374 | 147 | 78 | 4 | 68 | 202 | 416 | 557 | 5.41e-17 | 79.3 |
MS.gene61741.t1 | AT5G46760 | 33.557 | 149 | 82 | 6 | 68 | 202 | 415 | 560 | 3.70e-16 | 77.0 |
MS.gene61741.t1 | AT1G32640 | 32.414 | 145 | 86 | 3 | 68 | 202 | 452 | 594 | 6.95e-15 | 73.2 |
MS.gene61741.t1 | AT1G63650 | 32.857 | 140 | 76 | 4 | 68 | 189 | 405 | 544 | 1.42e-14 | 72.4 |
MS.gene61741.t1 | AT1G63650 | 32.857 | 140 | 76 | 4 | 68 | 189 | 405 | 544 | 1.42e-14 | 72.4 |
MS.gene61741.t1 | AT1G63650 | 32.857 | 140 | 76 | 4 | 68 | 189 | 405 | 544 | 1.42e-14 | 72.4 |
MS.gene61741.t1 | AT5G41315 | 30.345 | 145 | 78 | 4 | 68 | 189 | 441 | 585 | 8.45e-14 | 70.1 |
MS.gene61741.t1 | AT5G41315 | 30.345 | 145 | 78 | 4 | 68 | 189 | 446 | 590 | 9.05e-14 | 70.1 |
MS.gene61741.t1 | AT5G41315 | 30.345 | 145 | 78 | 4 | 68 | 189 | 449 | 593 | 9.24e-14 | 70.1 |
MS.gene61741.t1 | AT1G01260 | 36.842 | 95 | 57 | 1 | 68 | 162 | 433 | 524 | 3.72e-13 | 68.2 |
MS.gene61741.t1 | AT1G01260 | 36.842 | 95 | 57 | 1 | 68 | 162 | 433 | 524 | 3.72e-13 | 68.2 |
MS.gene61741.t1 | AT1G01260 | 36.842 | 95 | 57 | 1 | 68 | 162 | 433 | 524 | 3.72e-13 | 68.2 |
MS.gene61741.t1 | AT4G09820 | 32.231 | 121 | 62 | 1 | 69 | 189 | 364 | 464 | 5.92e-13 | 67.4 |
MS.gene61741.t1 | AT2G46510 | 45.714 | 70 | 35 | 1 | 68 | 134 | 395 | 464 | 8.04e-13 | 67.4 |
MS.gene61741.t1 | AT2G16910 | 30.968 | 155 | 85 | 5 | 69 | 201 | 315 | 469 | 2.97e-12 | 65.5 |
MS.gene61741.t1 | AT4G16430 | 44.262 | 61 | 34 | 0 | 68 | 128 | 320 | 380 | 2.29e-11 | 62.8 |
MS.gene61741.t1 | AT4G00870 | 32.624 | 141 | 76 | 4 | 51 | 179 | 230 | 363 | 9.42e-11 | 60.8 |
Find 0 sgRNAs with CRISPR-Local
Find 46 sgRNAs with CRISPR-GE
CRISPR-Local
sgRNA_sequence | on_target_score | Position | Region |
---|
CRISPR-GE
badsite warning | sgRNA_sequence | Strand | Position | Region | GC_content |
---|---|---|---|---|---|
!!! | TTCTTTTTATGAAATAATCT+TGG | + | 23899:492-511 | MS.gene61741:intron | 15.0% |
!!! | TAAAAAGCGTTTGAAATTTT+TGG | + | 23899:617-636 | MS.gene61741:CDS | 20.0% |
!!! | TAGGAAAATATATGTTGATT+CGG | + | 23899:781-800 | MS.gene61741:CDS | 20.0% |
!!! | TTACTTATTGTACCTTTTTA+AGG | - | 23899:461-480 | None:intergenic | 20.0% |
! | AACTGAAAAGATGATTTAGA+TGG | - | 23899:252-271 | None:intergenic | 25.0% |
! | TCTAGTTAAAATTATGGTTG+AGG | + | 23899:830-849 | MS.gene61741:CDS | 25.0% |
!! | AGGACTTCTAGTTAAAATTA+TGG | + | 23899:824-843 | MS.gene61741:CDS | 25.0% |
AAATTATGGTTGAGGTTCAA+AGG | + | 23899:838-857 | MS.gene61741:CDS | 30.0% | |
AATAATAGTGTCTTACCCTT+TGG | + | 23899:879-898 | MS.gene61741:CDS | 30.0% | |
TACTAATTCCTCACAAAACT+TGG | + | 23899:311-330 | MS.gene61741:CDS | 30.0% | |
TCAGTTTCAAATTCCATCTT+TGG | + | 23899:266-285 | MS.gene61741:CDS | 30.0% | |
TCTACGATAGAATTTCCAAA+GGG | - | 23899:897-916 | None:intergenic | 30.0% | |
! | TTTTGTGAGGAATTAGTAGT+GGG | - | 23899:309-328 | None:intergenic | 30.0% |
!! | AATTAGTAGTGGGTGAATTT+GGG | - | 23899:299-318 | None:intergenic | 30.0% |
!! | TGAAGAAAGTTTTGGTGAAA+AGG | - | 23899:226-245 | None:intergenic | 30.0% |
!! | TGTTGATTTACCATTTCAAG+TGG | + | 23899:746-765 | MS.gene61741:CDS | 30.0% |
!! | TTTTGTTTCCAAGTTTTGTG+AGG | - | 23899:322-341 | None:intergenic | 30.0% |
!!! | TATTGTACCTTTTTAAGGTC+AGG | - | 23899:456-475 | None:intergenic | 30.0% |
ATTCTTGCTTCCACTTGAAA+TGG | - | 23899:759-778 | None:intergenic | 35.0% | |
CAAAAACCTCAAAGAGCAAA+AGG | + | 23899:337-356 | MS.gene61741:CDS | 35.0% | |
CGATTGCGTAAAAATGTGTT+AGG | + | 23899:545-564 | MS.gene61741:intron | 35.0% | |
GTCTACGATAGAATTTCCAA+AGG | - | 23899:898-917 | None:intergenic | 35.0% | |
TCATGGTCAAGATCATATCA+TGG | + | 23899:371-390 | MS.gene61741:CDS | 35.0% | |
TCTTGTTCCTGACCTTAAAA+AGG | + | 23899:446-465 | MS.gene61741:CDS | 35.0% | |
TTGCGTAAAAATGTGTTAGG+TGG | + | 23899:548-567 | MS.gene61741:intron | 35.0% | |
! | GTTTTGTGAGGAATTAGTAG+TGG | - | 23899:310-329 | None:intergenic | 35.0% |
!! | ATTAGTAGTGGGTGAATTTG+GGG | - | 23899:298-317 | None:intergenic | 35.0% |
!! | GAATTAGTAGTGGGTGAATT+TGG | - | 23899:300-319 | None:intergenic | 35.0% |
AAAAGGTCTCGTACTCATCA+TGG | + | 23899:354-373 | MS.gene61741:CDS | 40.0% | |
CAAGTGGAAGCAAGAATCTT+AGG | + | 23899:762-781 | MS.gene61741:CDS | 40.0% | |
! | GATGGCGATGAAGAAAGTTT+TGG | - | 23899:234-253 | None:intergenic | 40.0% |
CTAGAAGTCCTTTGTGCTCT+TGG | - | 23899:815-834 | None:intergenic | 45.0% | |
TGCAAGGGCAATGAAGTTCT+GGG | - | 23899:424-443 | None:intergenic | 45.0% | |
! | ACGAGACCTTTTGCTCTTTG+AGG | - | 23899:346-365 | None:intergenic | 45.0% |
! | ATCCAATGCCAAGAGCACAA+AGG | + | 23899:804-823 | MS.gene61741:CDS | 45.0% |
!! | TTTGGGGTGTTGTCCAAAGA+TGG | - | 23899:282-301 | None:intergenic | 45.0% |
AATGCTCTCACGAGATGACG+AGG | - | 23899:718-737 | None:intergenic | 50.0% | |
AGGAGTTGTCATCGTTGCAG+AGG | - | 23899:698-717 | None:intergenic | 50.0% | |
CTGCAAGGGCAATGAAGTTC+TGG | - | 23899:425-444 | None:intergenic | 50.0% | |
GTCAGGAACAAGAGCTGCAA+GGG | - | 23899:439-458 | None:intergenic | 50.0% | |
GTCCTTTGTGCTCTTGGCAT+TGG | - | 23899:809-828 | None:intergenic | 50.0% | |
!! | CCTGGTTTGGTCAAGACTGT+CGG | - | 23899:675-694 | None:intergenic | 50.0% |
ATCGTTGCAGAGGCCTGGTT+TGG | - | 23899:688-707 | None:intergenic | 55.0% | |
CCGACAGTCTTGACCAAACC+AGG | + | 23899:672-691 | MS.gene61741:CDS | 55.0% | |
GGTCAGGAACAAGAGCTGCA+AGG | - | 23899:440-459 | None:intergenic | 55.0% | |
TTGTCATCGTTGCAGAGGCC+TGG | - | 23899:693-712 | None:intergenic | 55.0% |
Chromosome | Type | Strat | End | Strand | Name |
---|---|---|---|---|---|
23899 | gene | 180 | 935 | 180 | ID=MS.gene61741 |
23899 | mRNA | 180 | 935 | 180 | ID=MS.gene61741.t1;Parent=MS.gene61741 |
23899 | exon | 180 | 467 | 180 | ID=MS.gene61741.t1.exon1;Parent=MS.gene61741.t1 |
23899 | CDS | 180 | 467 | 180 | ID=cds.MS.gene61741.t1;Parent=MS.gene61741.t1 |
23899 | exon | 567 | 935 | 567 | ID=MS.gene61741.t1.exon2;Parent=MS.gene61741.t1 |
23899 | CDS | 567 | 935 | 567 | ID=cds.MS.gene61741.t1;Parent=MS.gene61741.t1 |
Gene Sequence |
Protein sequence |