Alfalfa Gene Editing Database
Nr:
| Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MS.gene89206.t1 | XP_024640360.1 | 95.9 | 611 | 25 | 0 | 1 | 611 | 1 | 611 | 2.3e-309 | 1070.8 |
Swissprot:
| Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MS.gene89206.t1 | Q6NU91 | 29.7 | 472 | 257 | 8 | 96 | 556 | 98 | 505 | 5.1e-52 | 207.2 |
Trembl:
| Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MS.gene89206.t1 | G7K1U1 | 95.3 | 611 | 25 | 1 | 1 | 611 | 1 | 607 | 1.4e-305 | 1057.7 |
TFs/TRs:
| Gene ID | Type | Classification |
|---|
Protein Kinases:
| Gene ID | Type | Classification |
|---|
Network:
Co-expression Network:
| Gene1 | Gene2 | correlation coefficient | p_value | FDR |
|---|
PPI:
| Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MS.gene89206.t1 | MTR_5g078780 | 94.781 | 594 | 27 | 1 | 18 | 611 | 18 | 607 | 0.0 | 1129 |
| MS.gene89206.t1 | MTR_5g078810 | 75.714 | 70 | 17 | 0 | 365 | 434 | 1 | 70 | 4.24e-26 | 102 |
| Query id | Subject id | identity % | alignment length | mismatches | gap openings | q. start | q. end | s. start | s. end | e-value | bit score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MS.gene89206.t1 | AT2G17250 | 58.333 | 576 | 229 | 5 | 12 | 583 | 8 | 576 | 0.0 | 678 |
Find 138 sgRNAs with CRISPR-Local
Find 0 sgRNAs with CRISPR-GE
CRISPR-Local
| sgRNA_sequence | on_target_score | Position | Region |
|---|---|---|---|
| TACATTATTGTTACGTTTCT+TGG | 0.096967 | 5.2:-67241380 | None:intergenic |
| AATGGTCAAGGCCTGATTTC+TGG | 0.177335 | 5.2:-67245611 | None:intergenic |
| CTTCATCTTCTTCGCAATTC+TGG | 0.241906 | 5.2:-67241616 | None:intergenic |
| TTGGAGGGAAAAGATGTTTC+AGG | 0.244460 | 5.2:+67240245 | MS.gene89206:CDS |
| TTGCTTTCAGTTCCACCTTC+TGG | 0.244476 | 5.2:+67244029 | MS.gene89206:CDS |
| AGAAAAGCTCACAAGAAATT+TGG | 0.246404 | 5.2:+67240226 | MS.gene89206:CDS |
| CTTGAGCAGGAAGCTCTCTT+TGG | 0.255727 | 5.2:+67246091 | MS.gene89206:intron |
| TTTAGGTTTGCTTTGTCTCT+TGG | 0.268396 | 5.2:+67246277 | MS.gene89206:intron |
| CAGATTCCTCAATGTTAAAA+TGG | 0.289979 | 5.2:-67245629 | None:intergenic |
| GAACGGGGCTAAAGATTTAT+TGG | 0.290532 | 5.2:+67246910 | MS.gene89206:CDS |
| AAGCTTGGATTGCGTATCTT+AGG | 0.300738 | 5.2:+67241652 | MS.gene89206:CDS |
| CCAATCCATGCTGGGTCATT+AGG | 0.303403 | 5.2:-67242847 | None:intergenic |
| TTAGGTTTGCTTTGTCTCTT+GGG | 0.321498 | 5.2:+67246278 | MS.gene89206:intron |
| GCTTCTTATGCAACAATACT+TGG | 0.323139 | 5.2:+67246358 | MS.gene89206:CDS |
| ATTAGTTCCATCTATCTTCA+TGG | 0.328121 | 5.2:+67242904 | MS.gene89206:CDS |
| TGAGCTTAATTGACTTTCAT+TGG | 0.332356 | 5.2:-67240434 | None:intergenic |
| TGAATGCGATGAAACTATTA+AGG | 0.339514 | 5.2:+67239403 | MS.gene89206:CDS |
| GAAGGGAGTTGAGGGAGGAG+AGG | 0.348058 | 5.2:-67239257 | None:intergenic |
| GTGGTGGTTGCGGTGGCGGA+AGG | 0.353194 | 5.2:-67239275 | None:intergenic |
| ATGTGGTGAGGTGGAGAAGA+AGG | 0.362280 | 5.2:-67239197 | None:intergenic |
| GCTGGTGGTGGTTGCGGTGG+CGG | 0.371522 | 5.2:-67239279 | None:intergenic |
| TCAGTGATGCTGTGTTGTTT+TGG | 0.385668 | 5.2:-67239095 | None:intergenic |
| ACCCCTTCTTCCAGCTTACC+TGG | 0.387473 | 5.2:+67243974 | MS.gene89206:CDS |
| TGCATTGGTTATTACAGCTC+TGG | 0.389369 | 5.2:+67244052 | MS.gene89206:CDS |
| GCTGGGTCATTAGGATATAA+AGG | 0.391038 | 5.2:-67242838 | None:intergenic |
| AAAACAAGCGAAGTTAATAT+TGG | 0.391828 | 5.2:+67246322 | MS.gene89206:CDS |
| TTGAGCAGGAAGCTCTCTTT+GGG | 0.394155 | 5.2:+67246092 | MS.gene89206:intron |
| CTGGAAGAAGGGGTGACTTT+AGG | 0.399170 | 5.2:-67243965 | None:intergenic |
| TGTGGTGAGGTGGAGAAGAA+GGG | 0.400686 | 5.2:-67239196 | None:intergenic |
| GAGTTTGTTAAGGTTGCTAA+TGG | 0.401292 | 5.2:+67239449 | MS.gene89206:CDS |
| CGAAGAGACTGCTTCTAACT+TGG | 0.405411 | 5.2:+67245560 | MS.gene89206:CDS |
| GAGATGAATGTGAGGAGGAG+AGG | 0.410717 | 5.2:-67239173 | None:intergenic |
| AGATGAATGTGAGGAGGAGA+GGG | 0.412733 | 5.2:-67239172 | None:intergenic |
| AAGGGAGTTGAGGGAGGAGA+GGG | 0.413318 | 5.2:-67239256 | None:intergenic |
| CGATCAACTGTTTGGTGCAC+CGG | 0.416098 | 5.2:+67244102 | MS.gene89206:CDS |
| GCAAAGCTCTGCCAGAAATC+AGG | 0.417403 | 5.2:+67245600 | MS.gene89206:CDS |
| TTAGAAATGTGGAGTGTATC+AGG | 0.418848 | 5.2:+67240879 | MS.gene89206:CDS |
| CCACGTGAGGTAAATGAATT+CGG | 0.420969 | 5.2:-67239324 | None:intergenic |
| GGAGGAGCTGGTGGTGGTTG+CGG | 0.422441 | 5.2:-67239285 | None:intergenic |
| TCATCGACAATAATGAGAAC+GGG | 0.429049 | 5.2:+67246894 | MS.gene89206:CDS |
| TCTTAGGTTGCCACTTCCAT+TGG | 0.431065 | 5.2:+67241668 | MS.gene89206:CDS |
| TACTTTGATGGAGTTTGTTA+AGG | 0.432512 | 5.2:+67239439 | MS.gene89206:CDS |
| AGTTGTGCTTGATACTTTGA+TGG | 0.436883 | 5.2:+67239427 | MS.gene89206:CDS |
| AGTTCCACCTTCTGGTGCAT+TGG | 0.437968 | 5.2:+67244037 | MS.gene89206:CDS |
| ACATCCTTCGATCAACTGTT+TGG | 0.439932 | 5.2:+67244094 | MS.gene89206:CDS |
| TGTCTAATCCCATCATGTTA+TGG | 0.440426 | 5.2:+67242675 | MS.gene89206:CDS |
| AGGGAGGAGAGGGAGGAAGA+AGG | 0.440748 | 5.2:-67239246 | None:intergenic |
| GGAGTTGAGGGAGGAGAGGG+AGG | 0.440858 | 5.2:-67239253 | None:intergenic |
| AGTTAAAATTTACTAAAGCT+TGG | 0.442017 | 5.2:+67241637 | MS.gene89206:CDS |
| CTCATAGCGCCTGACTTCAT+AGG | 0.448545 | 5.2:-67245654 | None:intergenic |
| AATGAGGCAGCCAGGTAAGC+TGG | 0.457951 | 5.2:-67243984 | None:intergenic |
| TGGTGGTTGCGGTGGCGGAA+GGG | 0.462845 | 5.2:-67239274 | None:intergenic |
| CGGTGGCGGAAGGGAGTTGA+GGG | 0.464726 | 5.2:-67239265 | None:intergenic |
| ACCACCACCAGCTCCTCCTC+TGG | 0.470797 | 5.2:+67239290 | MS.gene89206:CDS |
| TTTCTTCATTGCAGGTTCCA+TGG | 0.470904 | 5.2:-67239048 | None:intergenic |
| TTGGGTATTCCAATCCATGC+TGG | 0.473646 | 5.2:-67242856 | None:intergenic |
| GTTGTTGATGTGTGAGGCGG+AGG | 0.482954 | 5.2:-67239147 | None:intergenic |
| CCTAATGACCCAGCATGGAT+TGG | 0.485238 | 5.2:+67242847 | MS.gene89206:CDS |
| CAGCCAGGTAAGCTGGAAGA+AGG | 0.488496 | 5.2:-67243977 | None:intergenic |
| AGCCAGGTAAGCTGGAAGAA+GGG | 0.489279 | 5.2:-67243976 | None:intergenic |
| ATTTCAAGTATATTGATGTT+CGG | 0.489524 | 5.2:+67239687 | MS.gene89206:CDS |
| ACTCAATTTCTTTGCAAATG+AGG | 0.492729 | 5.2:-67244000 | None:intergenic |
| CAAAACACTTACCGTGAGAC+AGG | 0.494028 | 5.2:-67246147 | None:intergenic |
| GAAGAGAGAGAATCGATTCG+AGG | 0.495834 | 5.2:-67239220 | None:intergenic |
| GGAGAGAAGTTCTTGACCTA+AGG | 0.496473 | 5.2:-67239126 | None:intergenic |
| GTGGTGAGGTGGAGAAGAAG+GGG | 0.502021 | 5.2:-67239195 | None:intergenic |
| TGAATGTGAGGAGGAGAGGG+AGG | 0.502763 | 5.2:-67239169 | None:intergenic |
| ATCACTGAAATCAAAACCTT+AGG | 0.502878 | 5.2:+67239110 | MS.gene89206:CDS |
| GAATCTGATCCTATGAAGTC+AGG | 0.505902 | 5.2:+67245645 | MS.gene89206:CDS |
| TTGACAAGGTCGTATGATGT+AGG | 0.506754 | 5.2:+67242785 | MS.gene89206:CDS |
| TTCTCTGAAAAGAGAGAGGA+TGG | 0.507254 | 5.2:-67246824 | None:intergenic |
| GTAAATGAATTCGGATTGAT+CGG | 0.509695 | 5.2:-67239315 | None:intergenic |
| GATTACACGGAGGGTGAAGC+AGG | 0.509973 | 5.2:+67246775 | MS.gene89206:intron |
| TCTTTGCAAATGAGGCAGCC+AGG | 0.517329 | 5.2:-67243992 | None:intergenic |
| ATCGGAACCAGAGGAGGAGC+TGG | 0.519725 | 5.2:-67239297 | None:intergenic |
| GGAGCTGGTGGTGGTTGCGG+TGG | 0.521533 | 5.2:-67239282 | None:intergenic |
| TGGGTATTCCAATCCATGCT+GGG | 0.522547 | 5.2:-67242855 | None:intergenic |
| AATAATAACTTACAATACTA+CGG | 0.526362 | 5.2:-67239508 | None:intergenic |
| TTTGTTAAGGTTGCTAATGG+TGG | 0.527835 | 5.2:+67239452 | MS.gene89206:CDS |
| AGAGAATCGATTCGAGGATG+TGG | 0.533005 | 5.2:-67239214 | None:intergenic |
| ACCAGAGGAGGAGCTGGTGG+TGG | 0.535853 | 5.2:-67239291 | None:intergenic |
| AAGAAGGGGAGATGAATGTG+AGG | 0.536341 | 5.2:-67239181 | None:intergenic |
| CCGAATTCATTTACCTCACG+TGG | 0.537243 | 5.2:+67239324 | MS.gene89206:CDS |
| GCGGTGGCGGAAGGGAGTTG+AGG | 0.538128 | 5.2:-67239266 | None:intergenic |
| GATAAAACTGCAAGCGCAGA+TGG | 0.542599 | 5.2:+67240409 | MS.gene89206:CDS |
| ATCACTTATCGATTGTCTTG+TGG | 0.543229 | 5.2:+67239376 | MS.gene89206:CDS |
| ATGAAAGTCAATTAAGCTCA+AGG | 0.545065 | 5.2:+67240437 | MS.gene89206:CDS |
| GAGGAATCACTGCTTGGTGA+AGG | 0.547446 | 5.2:-67242649 | None:intergenic |
| GGCTAAAGATTTATTGGACC+AGG | 0.548798 | 5.2:+67246916 | MS.gene89206:CDS |
| ACCTCTTTGAACACATCCAA+TGG | 0.549353 | 5.2:-67241684 | None:intergenic |
| GATCAACTGTTTGGTGCACC+GGG | 0.550891 | 5.2:+67244103 | MS.gene89206:CDS |
| AAAGCTCACAAGAAATTTGG+AGG | 0.555352 | 5.2:+67240229 | MS.gene89206:CDS |
| TTGAACACATCCAATGGAAG+TGG | 0.555934 | 5.2:-67241678 | None:intergenic |
| GCCAGGTAAGCTGGAAGAAG+GGG | 0.560855 | 5.2:-67243975 | None:intergenic |
| AGGTGTTTACCATAACATGA+TGG | 0.563701 | 5.2:-67242684 | None:intergenic |
| TCCATTGGATGTGTTCAAAG+AGG | 0.564996 | 5.2:+67241683 | MS.gene89206:CDS |
| GGTGTTTACCATAACATGAT+GGG | 0.565453 | 5.2:-67242683 | None:intergenic |
| ATATGGTGTAGTACATATTG+TGG | 0.566500 | 5.2:-67240815 | None:intergenic |
| AAGGGGAGATGAATGTGAGG+AGG | 0.575380 | 5.2:-67239178 | None:intergenic |
| AGGGAGGTTGTTGATGTGTG+AGG | 0.576196 | 5.2:-67239153 | None:intergenic |
| TTGCACCATTGCAGATTACA+CGG | 0.577570 | 5.2:+67246762 | MS.gene89206:intron |
| TGGCGGAAGGGAGTTGAGGG+AGG | 0.579360 | 5.2:-67239262 | None:intergenic |
| CCTCAATGTTAAAATGGTCA+AGG | 0.580409 | 5.2:-67245623 | None:intergenic |
| AACTTGGATAATGCTCAGAA+TGG | 0.586561 | 5.2:+67245576 | MS.gene89206:CDS |
| AGACAGGAGGACAGTAGTGG+TGG | 0.591867 | 5.2:-67246131 | None:intergenic |
| ACAGATGAGGAATCACTGCT+TGG | 0.595439 | 5.2:-67242655 | None:intergenic |
| GATTCGAGGATGTGGTGAGG+TGG | 0.595441 | 5.2:-67239206 | None:intergenic |
| TCATGGCAAAACATCGTGCA+AGG | 0.595702 | 5.2:+67242921 | MS.gene89206:CDS |
| ACCATTGCAGATTACACGGA+GGG | 0.596485 | 5.2:+67246766 | MS.gene89206:intron |
| TTATGCAACAATACTTGGAG+CGG | 0.600906 | 5.2:+67246363 | MS.gene89206:CDS |
| TTCGGATTGATCGGAACCAG+AGG | 0.606360 | 5.2:-67239306 | None:intergenic |
| TATATCCTAATGACCCAGCA+TGG | 0.606697 | 5.2:+67242842 | MS.gene89206:CDS |
| GAGGTTGTTGATGTGTGAGG+CGG | 0.608742 | 5.2:-67239150 | None:intergenic |
| GAAATTCGTCGAACTTCGAA+CGG | 0.609958 | 5.2:-67239349 | None:intergenic |
| TGCAACAATACTTGGAGCGG+AGG | 0.610817 | 5.2:+67246366 | MS.gene89206:CDS |
| ACTTATCGATTGTCTTGTGG+CGG | 0.611390 | 5.2:+67239379 | MS.gene89206:CDS |
| ATCATCGACAATAATGAGAA+CGG | 0.612651 | 5.2:+67246893 | MS.gene89206:CDS |
| ATCATTCTCTGAAAAGAGAG+AGG | 0.615510 | 5.2:-67246828 | None:intergenic |
| ATAACCAATGCACCAGAAGG+TGG | 0.616650 | 5.2:-67244041 | None:intergenic |
| TGCACCAAACAGTTGATCGA+AGG | 0.618010 | 5.2:-67244098 | None:intergenic |
| CATATTGTGGATGATGCACT+CGG | 0.624795 | 5.2:-67240802 | None:intergenic |
| ATACATCTGATTTAGAAATG+TGG | 0.629117 | 5.2:+67240868 | MS.gene89206:CDS |
| ACTACTGTCCTCCTGTCTCA+CGG | 0.630327 | 5.2:+67246136 | MS.gene89206:CDS |
| GTAATAACCAATGCACCAGA+AGG | 0.635450 | 5.2:-67244044 | None:intergenic |
| AAGCTCACAAGAAATTTGGA+GGG | 0.638699 | 5.2:+67240230 | MS.gene89206:CDS |
| GGAACCAGAGGAGGAGCTGG+TGG | 0.642590 | 5.2:-67239294 | None:intergenic |
| ATCGATTCGAGGATGTGGTG+AGG | 0.646651 | 5.2:-67239209 | None:intergenic |
| GTGAGACAGGAGGACAGTAG+TGG | 0.650028 | 5.2:-67246134 | None:intergenic |
| CATTTGCAAAGAAATTGAGT+AGG | 0.655411 | 5.2:+67244003 | MS.gene89206:CDS |
| ACTTCGAACGGAGCCACGTG+AGG | 0.663920 | 5.2:-67239337 | None:intergenic |
| TGTGCAGTGATTTCTTGACA+AGG | 0.666059 | 5.2:+67242771 | MS.gene89206:intron |
| GGATTGATCGGAACCAGAGG+AGG | 0.668743 | 5.2:-67239303 | None:intergenic |
| AGGTGGTGTAGTCAGCGTGA+TGG | 0.671351 | 5.2:+67242805 | MS.gene89206:CDS |
| AACACTTACCGTGAGACAGG+AGG | 0.675774 | 5.2:-67246144 | None:intergenic |
| CATCGACAATAATGAGAACG+GGG | 0.677716 | 5.2:+67246895 | MS.gene89206:CDS |
| ACAAGGTCGTATGATGTAGG+TGG | 0.691770 | 5.2:+67242788 | MS.gene89206:CDS |
| ATGATGGGATTAGACAGATG+AGG | 0.697642 | 5.2:-67242668 | None:intergenic |
| CACCATTGCAGATTACACGG+AGG | 0.732506 | 5.2:+67246765 | MS.gene89206:intron |
CRISPR-GE
| badsite warning | sgRNA_sequence | Strand | Position | Region | GC_content |
|---|
| Chromosome | Type | Strat | End | Strand | Name |
|---|---|---|---|---|---|
| chr5.2 | gene | 67239050 | 67246979 | 67239050 | ID=MS.gene89206 |
| chr5.2 | mRNA | 67239050 | 67246979 | 67239050 | ID=MS.gene89206.t1;Parent=MS.gene89206 |
| chr5.2 | exon | 67239050 | 67239517 | 67239050 | ID=MS.gene89206.t1.exon1;Parent=MS.gene89206.t1 |
| chr5.2 | CDS | 67239050 | 67239517 | 67239050 | ID=cds.MS.gene89206.t1;Parent=MS.gene89206.t1 |
| chr5.2 | exon | 67239635 | 67239708 | 67239635 | ID=MS.gene89206.t1.exon2;Parent=MS.gene89206.t1 |
| chr5.2 | CDS | 67239635 | 67239708 | 67239635 | ID=cds.MS.gene89206.t1;Parent=MS.gene89206.t1 |
| chr5.2 | exon | 67240205 | 67240266 | 67240205 | ID=MS.gene89206.t1.exon3;Parent=MS.gene89206.t1 |
| chr5.2 | CDS | 67240205 | 67240266 | 67240205 | ID=cds.MS.gene89206.t1;Parent=MS.gene89206.t1 |
| chr5.2 | exon | 67240407 | 67240458 | 67240407 | ID=MS.gene89206.t1.exon4;Parent=MS.gene89206.t1 |
| chr5.2 | CDS | 67240407 | 67240458 | 67240407 | ID=cds.MS.gene89206.t1;Parent=MS.gene89206.t1 |
| chr5.2 | exon | 67240800 | 67240900 | 67240800 | ID=MS.gene89206.t1.exon5;Parent=MS.gene89206.t1 |
| chr5.2 | CDS | 67240800 | 67240900 | 67240800 | ID=cds.MS.gene89206.t1;Parent=MS.gene89206.t1 |
| chr5.2 | exon | 67241350 | 67241399 | 67241350 | ID=MS.gene89206.t1.exon6;Parent=MS.gene89206.t1 |
| chr5.2 | CDS | 67241350 | 67241399 | 67241350 | ID=cds.MS.gene89206.t1;Parent=MS.gene89206.t1 |
| chr5.2 | exon | 67241603 | 67241704 | 67241603 | ID=MS.gene89206.t1.exon7;Parent=MS.gene89206.t1 |
| chr5.2 | CDS | 67241603 | 67241704 | 67241603 | ID=cds.MS.gene89206.t1;Parent=MS.gene89206.t1 |
| chr5.2 | exon | 67242638 | 67242696 | 67242638 | ID=MS.gene89206.t1.exon8;Parent=MS.gene89206.t1 |
| chr5.2 | CDS | 67242638 | 67242696 | 67242638 | ID=cds.MS.gene89206.t1;Parent=MS.gene89206.t1 |
| chr5.2 | exon | 67242778 | 67242952 | 67242778 | ID=MS.gene89206.t1.exon9;Parent=MS.gene89206.t1 |
| chr5.2 | CDS | 67242778 | 67242952 | 67242778 | ID=cds.MS.gene89206.t1;Parent=MS.gene89206.t1 |
| chr5.2 | exon | 67243951 | 67244124 | 67243951 | ID=MS.gene89206.t1.exon10;Parent=MS.gene89206.t1 |
| chr5.2 | CDS | 67243951 | 67244124 | 67243951 | ID=cds.MS.gene89206.t1;Parent=MS.gene89206.t1 |
| chr5.2 | exon | 67245525 | 67245675 | 67245525 | ID=MS.gene89206.t1.exon11;Parent=MS.gene89206.t1 |
| chr5.2 | CDS | 67245525 | 67245675 | 67245525 | ID=cds.MS.gene89206.t1;Parent=MS.gene89206.t1 |
| chr5.2 | exon | 67246100 | 67246157 | 67246100 | ID=MS.gene89206.t1.exon12;Parent=MS.gene89206.t1 |
| chr5.2 | CDS | 67246100 | 67246157 | 67246100 | ID=cds.MS.gene89206.t1;Parent=MS.gene89206.t1 |
| chr5.2 | exon | 67246282 | 67246387 | 67246282 | ID=MS.gene89206.t1.exon13;Parent=MS.gene89206.t1 |
| chr5.2 | CDS | 67246282 | 67246387 | 67246282 | ID=cds.MS.gene89206.t1;Parent=MS.gene89206.t1 |
| chr5.2 | exon | 67246776 | 67246979 | 67246776 | ID=MS.gene89206.t1.exon14;Parent=MS.gene89206.t1 |
| chr5.2 | CDS | 67246776 | 67246979 | 67246776 | ID=cds.MS.gene89206.t1;Parent=MS.gene89206.t1 |
| Gene Sequence |
| Protein sequence |